@article { ISI:000378790600010,
	title = {Anti-oxidant properties of ficus religiosa L. Bark extract on human keratinocytes},
	journal = {Science of Advanced Materials},
	volume = {8},
	number = {6},
	year = {2016},
	month = {JUN},
	pages = {1221-1226},
	publisher = {AMER SCIENTIFIC PUBLISHERS},
	address = {26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA},
	abstract = {<p>Ficus religiosa (Sacred Fig) is a medicinally important tree, native to the Indian subcontinent. It has been extensively pharmacologically researched species having wide spectrum of medicinal properties. All parts of F. religiosa tree are known to possess important medicinal properties such as anti-oxidant, anti-inflammatory, wound healing and skin diseases etc. However, effects of F. religiosa on skin cells line HaCaT was not studied for its antioxidant properties. In this report we have investigated F. religiosa bark aqueous extract for its antioxidant properties on human keratinocytes (HaCaT) cell line using DPPH, superoxide dismutase 1, superoxide dismutase 2 and catalase assay. We observed that F. religiosa bark aqueous extract efficiently scavenged (80\%) DPPH radicals. Superoxide dismutase1 assay of F. religiosa bark aqueous extract effectively scavenged superoxide radicals (O-2(-)) and showed dose dependent activity. Reactive oxygen species were trapped by superoxide dismutase 2 assay of F. religiosa bark aqueous extract and form hydrogen peroxide. Catalase assay results revelled that hydrogen peroxide was further decomposed to give water and oxygen. Thus various anti-oxidant assays of F. religiosa bark aqueous extract indicate that it efficiently reduced the reactive oxygen species in skin cells.</p>},
	keywords = {Anti-Oxidant, Catalase Assay, DPPH Assay, Ficus religiosa, Keratinocyte HaCaT Cell Line, Moraceae, SOD Assay},
	issn = {1947-2935},
	doi = {10.1166/sam.2016.2740},
	author = {Dixit, Shailesh S. and Kulkarni, Atul and Seo, Hyo Hyun and Gadgil, Jayant and Dingre, Medini and Umar, Ahmad and Moh, Sang Hyun and Parasharami, Varsha A.}
}
@article {46826,
	title = {Synthesis of novel of 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives and their in vitro anti-inflammatory, anti-oxidant evaluation, and molecular docking study},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	volume = {30},
	year = {2020},
	month = {JUN},
	pages = {127136},
	type = {Article},
	abstract = {<p>A series of novel 2, 5-disubstituted 1, 3, 4-Oxadiazole derivatives as a potential anti-inflammatory, and antioxidant agent were synthesized via cyclisation. Hydrazide molecule treated with substituted acids in the presence of phosphorus oxychloride (POCl3) as an efficient reagent as well as solvent by conventional method with shorter reaction time and excellent yield. The newly synthesized 1, 3, 4-oxadiazole derivatives exhibited excellent to good anti-inflammatory and anti-oxidant activities compaired to the standard drugs. Molecular docking study on the crucial anti-inflammatory target-cyclooxygenase-2 (COX-2) revealed the ability of the scaffold to correctly recognize the active site and achieve significant bonded and non-bonded interactions with key residues therein. This study could identify potential compounds which can be pertinent starting points for structure-based drug design to obtain newer anti-inflammatory agents.</p>
},
	keywords = {1, 3, 4-Oxadiazole, Anti-inflammatory, Anti-Oxidant, Biological activity, computational chemistry},
	issn = {0960-894X},
	doi = {10.1016/j.bmcl.2020.127136},
	author = {Kashid, Bharat B. and Salunkhe, Pravin H. and Dongare, Balasaheb B. and More, Kishor R. and Khedkar, Vijay M. and Ghanwat, Anil A.}
}
