@article { ISI:000229488700014,
	title = {Bronsted acidic ionic liquids: a green, efficient and reusable catalyst system and reaction medium for fischer esterification},
	journal = {Journal of Molecular Catalysis A - Chemical},
	volume = {234},
	number = {1-2},
	year = {2005},
	month = {JUN},
	pages = {107-110},
	publisher = {ELSEVIER SCIENCE BV},
	type = {Article},
	address = {PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS},
	abstract = {<p>Bronsted acidic ionic liquid containing nitrogen-based organic cations 1-methylimidazole and 1-butyl-3-methylimidazolium and inorganic anions of the type BF4-, PF6- and PTSA(-) has been synthesized in good yields and used as a catalysts and reaction medium for Fischer esterification of alcohols with acids. These were characterized using FTIR and NMR spectroscopy. Ionic liquids as catalyst afforded good alcohol conversion and excellent ester selectivity. Fischer esterification of acetic acid with benzyl alcohol with different Bronsted acidic ionic liquids was carried out. Maximum substrate conversion 100 \% and product selectivity 100 \% was observed on using [BMIM](+)PTSAas catalyst over a period of 2 h. The ester was easily separated from the reaction mixture and the ionic liquid was reused four times after removing water. No significant loss in catalytic activity was observed on recycling. (c) 2005 Elsevier B.V. All rights reserved.</p>},
	keywords = {acids, alcohol and reaction medium, Fischer esterification, Ionic liquid},
	issn = {1381-1169},
	doi = {10.1016/j.molcata.2005.03.005},
	author = {Joseph, Trissa and Sahoo, S. and Halligudi, Shivappa B.}
}
@article {48928,
	title = {Batch and continuous flow mechanochemical synthesis of organic compounds including APIs},
	journal = {Reaction Chemistry and  Engineering },
	volume = {9},
	year = {2023},
	month = {DEC },
	pages = {10-25},
	type = {Review},
	abstract = {<p>Mechanochemistry is becoming an enabling technology for the synthesis of organic and inorganic compounds as well as for the synthesis of polymers as it underlines sustainability in a significant manner. Continuous mechanochemical synthesis further adds value to the approach through consistency, smaller footprint, and better energy efficiency. This review gives an indepth view of the present status of this subject along with critical engineering aspects that one needs to measure and monitor as eventually synthesis needs to be transformed into a process. The examples covered herein include the synthesis of organic compounds, viz., APIs, agrochemical intermediates, catalysts, and polymers. In the end, we also discuss the safety aspects of mechanochemical synthesis and recommendations for exploring this field further. Mechanochemistry is becoming an enabling technology for the synthesis of organic and inorganic compounds as well as for the synthesis of polymers as it underlines sustainability in a significant manner.</p>
},
	keywords = {acids, Amides, Force, solvent},
	issn = {2058-9883},
	doi = {10.1039/d2re00521b},
	author = {Atapalkar, Ranjit S. and Kulkarni, Amol A.}
}
