@article { ISI:000249453100008,
	title = {4-Formylazetidin-2-one as a useful building block for the formal synthesis of xylo-(2S,3R,4R)-phytosphingosine and threo-(2S,3S)-sphingosine},
	journal = {Synthesis-Stuttgart },
	volume = {17},
	number = {17},
	year = {2007},
	month = {SEP},
	pages = {2631-2636},
	publisher = {GEORG THIEME VERLAG KG},
	type = {Article},
	address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY},
	abstract = {<p>Stereoselective formal synthesis of xylo-(2S,3R,4R)-phytosphingosine and threo-(2S,3S)-sphingosine is described starting from an enantiopure formyl-substituted P-lactam. Grignard reaction of the N-Boc-protected-beta-lactam carbonyl group, followed by further transformations, provides a common intermediate for xylo-(2S,3R,4R)-phytosphingosine and threo-(2S,3S)-sphingosine.</p>},
	keywords = {azetidin-2-one, beta-lactam, Grignard reaction, Phytosphingosine, Sphingosine},
	issn = {0039-7881},
	doi = {10.1055/s-2007-983815},
	author = {Kale, Ajaykumar S. and Sakle, Prathmesh S. and Gumaste, Vikas K. and Deshmukh, Abdul Rakeeb A. S.}
}
@article { ISI:000246298900004,
	title = {Practical formal synthesis of D-(+)-biotin from 4-formylazetidin-2-one},
	journal = {Synthesis-Stuttgart},
	number = {8},
	year = {2007},
	month = {APR},
	pages = {1159-1164},
	publisher = {GEORG THIEME VERLAG KG},
	type = {Article},
	address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY},
	abstract = {<p>A practical synthesis of (3S,6R)-1,3-dibenzyltetrahydro-1H-furo[3,4-d]imidazole-2,4-dione, an important intermediate in the synthesis of biotin, from 4-formyl-3-mesyloxyazetidin-2-one has been achieved. Acid-catalyzed azetidin-2-one ring opening followed by a one-pot conversion of diamine hydrochloride to a cyclic urea and hydroxymethylene to chloromethylene by triphosgene to obtain (4S,5R)-methyl-1,3-dibenzyl-5-chloromethyl-2-oxoimidazolidine-4-carboxyl ate is the key step in this synthesis.</p>},
	keywords = {azetidin-2-one, beta-Lactams, cyclization, Lactone, reduction},
	issn = {0039-7881},
	doi = {10.1055/s-2007-965992},
	author = {Kale, Ajaykumar S. and Puranik, Vedavati G. and Deshmukh, Abdul Rakeeb A. S.}
}
