@article { ISI:000249627100033, title = {Practical formal synthesis of camptothecin}, journal = {Tetrahedron Letter}, volume = {48}, number = {37}, year = {2007}, month = {SEP}, pages = {6561-6563}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, type = {Article}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

The synthesis of the DE ring of camptothecin using simple and inexpensive starting materials, employing an addition elimination reaction and selective esterification of an aliphatic carboxylic acid as key steps is described. (C) 2007 Elsevier Ltd. All rights reserved.

}, keywords = {alkaloid, Anticancer, camptothecin, Natural product}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2007.07.017}, author = {Chavan, Subhash P. and Pathak, Ashok B. and Kalkote, Uttam R.} } @article { ISI:000247620500052, title = {Total synthesis of pulchellalactam via an RCM strategy}, journal = {Synthetic Communications}, volume = {37}, number = {7-9}, year = {2007}, month = {MAY}, pages = {1503-1510}, publisher = {TAYLOR \& FRANCIS INC}, type = {Article}, address = {325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA}, abstract = {

Total synthesis of (Z) pulchellalactam, a CD protein tyrosine phosphatase inhibitor, from commercially available methallyl chloride employing ring-closure metathesis (RCM) as a key step is described.

}, keywords = {alkaloid, Natural products, pulchellalactam, RCM, Total synthesis}, issn = {0039-7911}, doi = {10.1080/00397910701229131}, author = {Chavan, Subhash P. and Pathak, Ashok B. and Dhawane, Abasaheb N. and Kalkote, Uttam R.} } @article { ISI:000282106400002, title = {Concise synthesis of (2S,3S,4S)-2-(Hydroxymethyl)pyrrolidine-3,4-diol (LAB1)}, journal = {Synthesis-Stuttgart}, number = {18}, year = {2010}, month = {SEP}, pages = {3063-3066}, publisher = {GEORG THIEME VERLAG KG}, address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY}, abstract = {

The synthesis of (2S,3S,4S)-2-(hydroxymethyl)pyrrolidine-3,4-diol (LAB1) from Garner{\textquoteright}s aldehyde is described using the Sharpless asymmetric dihydroxylation as the key step.

}, keywords = {alkaloid, azasugars, diastereoselectivity, Garner{\textquoteright}s aldehyde, pyrrolidine, Wittig reaction}, issn = {0039-7881}, doi = {10.1055/s-0030-1258185}, author = {Upadhyay, Puspesh K. and Kumar, Pradeep} } @article {47499, title = {Diversity in chemical structures and biological properties of plant alkaloids}, journal = {Molecules}, volume = {26}, year = {2021}, month = {JUN}, pages = {3374}, type = {Review}, abstract = {Phytochemicals belonging to the group of alkaloids are signature specialized metabolites endowed with countless biological activities. Plants are armored with these naturally produced nitrogenous compounds to combat numerous challenging environmental stress conditions. Traditional and modern healthcare systems have harnessed the potential of these organic compounds for the treatment of many ailments. Various chemical entities (functional groups) attached to the central moiety are responsible for their diverse range of biological properties. The development of the characterization of these plant metabolites and the enzymes involved in their biosynthesis is of an utmost priority to deliver enhanced advantages in terms of biological properties and productivity. Further, the incorporation of whole/partial metabolic pathways in the heterologous system and/or the overexpression of biosynthetic steps in homologous systems have both become alternative and lucrative methods over chemical synthesis in recent times. Moreover, in-depth research on alkaloid biosynthetic pathways has revealed numerous chemical modifications that occur during alkaloidal conversions. These chemical reactions involve glycosylation, acylation, reduction, oxidation, and methylation steps, and they are usually responsible for conferring the biological activities possessed by alkaloids. In this review, we aim to discuss the alkaloidal group of plant specialized metabolites and their brief classification covering major categories. We also emphasize the diversity in the basic structures of plant alkaloids arising through enzymatically catalyzed structural modifications in certain plant species, as well as their emerging diverse biological activities. The role of alkaloids in plant defense and their mechanisms of action are also briefly discussed. Moreover, the commercial utilization of plant alkaloids in the marketplace displaying various applications has been enumerated.}, keywords = {alkaloid, Biological activity, classification, defense, Enzyme, modification}, doi = {10.3390/molecules26113374}, author = {Bhambhani, Sweta and Kondhare, Kirtikumar R. and Giri, Ashok P.} }