@article { ISI:000295422000005,
	title = {Sesquiterpene lactone, a potent drug molecule from artemisia pallens wall with anti-inflammatory activity},
	journal = {Arzneimittel-Forschung-Drug Research},
	volume = {61},
	number = {9},
	year = {2011},
	month = {DEC},
	pages = {510-514},
	publisher = {ECV-EDITIO CANTOR VERLAG MEDIZIN NATURWISSENSCHAFTEN},
	address = {BANDELSTOCKWEG 20, POSTFACH 1255, D-88322 AULENDORF, GERMANY},
	abstract = {<p>The present study was carried out to investigate the anti-inflammatory activities of bioactive secondary metabolites of Artemisia pallens Wall, an aromatic herb from family Asteraceae. The results provide evidence for the topical anti-inflammatory properties of Artemisia pallens Wall. The compounds were isolated from the acetone extract of the plant material. The isolates were tested on Swiss albino mice using 12-O-tetradecanoyl phorbol-13-acetate (TPA) induced ear edema. One of the molecules from the extract indicated potent anti-inflammatory activity equivalent to indometacin (CAS 53-86-1). Elucidation of the molecular structures by single crystal x-ray diffraction studies revealed the conformational differences that the six membered rings in both the molecules are at an angle of 28.79 degrees. Presence of hydroxy function for compound 2 may be responsible for higher potency.</p>},
	keywords = {Anti-inflammatory activity, Artemisia pollens, Asteraceae, Mice, Single crystal x-ray structure},
	issn = {0004-4172},
	author = {Ruikar, Anjali D. and Misar, Ashwini V. and Jadhav, Ravindra B. and Rojatkar, Supada R. and Mujumdar, Arvind M. and Puranik, Vedavati G. and Deshpande, Nirmala R.}
}
@article {45536,
	title = {Phytochemical profile, anti-oxidant, anti-inflammatory, and anti-proliferative activities of Pogostemon deccanensis essential oils},
	journal = {3 Biotech},
	volume = {9},
	year = {2019},
	month = {JAN},
	pages = {31},
	type = {Article},
	abstract = {<p>Essential oils (EOs) obtained from aerial parts of Pogostemon deccanensis were analyzed for GC-MS profiling, and evaluated for antioxidant, anti-inflammatory, and anti-proliferative activities. GC-MS analysis revealed a total of 47 constituents, establishing the EOs rich in sesquiterpene with \&gt;20 sesquiterpenes constituting around 77\% of the total EO yield. Major constituents included Curzerene (Benzofuran, 6-ethenyl-4,5,6,7-tetrahydro-3,6-dimethyl-5-isopropenyl-, trans-) (26.39\%) and epi-Cadinol (22.68\%), Ethanone, 1-(2,4,6-trihydroxyphenyl) (6.83\%, Acetophenones), and Boldenone (3.47\%, anabolic steroid). EOs found to be rich in phytochemicals attributed for antioxidant potentials of aromatic/medicinal plants, viz., flavonoids (2.71 mu g quercetin equivalents g(-1) EO), total phenols (3.94 mu g gallic acid equivalents (GAE) g(-1) EO), carotenoids (14.3 mu g -carotene equivalents g(-1) EO), and ascorbic acid (2.21 mu g ascorbic acid equivalents g(-1) EO). P. deccanensis EOs exhibited striking antioxidant activities assessed by wide range of assays including ferric reducing antioxidant potential (FRAP, 255.3 GAE at 2 mu g mL(-1) EO), total antioxidant activity (TAA, 264.3 GAE at 2 mu g ml(-1)) of EO, DPPH (65\% inhibition at 2 mu g mL(-1)), and OH (58\% inhibition at 2 mu g mL(-1)) scavenging. Interestingly, EOs showed considerably higher anti-lipid peroxidation activity than the standard antioxidant molecule ascorbic acid, with 50\% protection by 1.29 mu g mL(-1) EO against 20.0 mu g mL(-1) standard. EOs showed strong anti-inflammatory activity with 50\% inhibition at 1.95 mu g mL(-1) EO. The anti-proliferative activity of EOs was tested against mouse cancer cell line and the EOs proved a potent anti-proliferative agent with only 2.1\% cell survival at 2 mu g mL(-1) EO, whereas the EOs were largely non-toxic-to-normal (non-cancerous) cells with approximately 80\% cell survival at the 2 mu g mL(-1) EOs. This being the first attempt of phytochemical profiling and wide array of biological activities of P. deccanensis EOs holds significance as the striking activities were observed at very low concentrations, in some cases at lower than the commercial standards, and has, therefore, great potential for pharmaceutical or commercial exploration.</p>},
	keywords = {Anti-inflammatory activity, Anti-proliferative activity, Antioxidants, Cytotoxicity, Essential oils},
	issn = {2190-572X},
	doi = {10.1007/s13205-018-1560-0},
	author = {Kumar, Vinay and Shriram, Varsha and Bhagat, Rani and Khare, Tushar and Kapse, Shivanjali and Kadoo, Narendra}
}
