@article { ISI:000230023600015, title = {Expedient synthesis of 1,2,3-triazole-fused tetracyclic compounds by intramolecular Huisgen ({\textquoteright}click{\textquoteright}) reactions on carbohydrate-derived azido-alkynes}, journal = {Tetrahedron Letters}, volume = {46}, number = {27}, year = {2005}, month = {JUL}, pages = {4585-4588}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, type = {Article}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

An efficient, practical and convenient synthesis of 1,2,3-triazole-fused tetracyclic compounds was achieved by intramolecular 1,3-dipolar cycloaddition of carbohydrate-derived azido-alkynes. (c) 2005 Elsevier Ltd. All rights reserved.

}, keywords = {carbohydrates, Click chemistry, Cycloaddition, diversity oriented synthesis, Huisgen reaction}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2005.05.012}, author = {Hotha, Srinivas and Anegundi, Ramakrishna I. and Natu, A. A.} } @article { ISI:000231712000007, title = {Synthesis of bile acid dimers linked with 1,2,3-triazole ring at C-3, C-11, and C-24 positions}, journal = {Synlett}, number = {14}, year = {2005}, month = {SEP}, pages = {2155-2158}, publisher = {GEORG THIEME VERLAG KG}, type = {Article}, address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY}, abstract = {

1,3-Dipolar cycloaddition of propargyl ester of a bile acid to an azide group attached at different positions of another bile acid gave three new 1,2,3-triazole-containing dimeric analogues in excellent yields.

}, keywords = {1, 2, 3-dipolar cycloaddition, 3-Triazole, Bile acids, Click chemistry, steroidal dimers}, issn = {0936-5214}, doi = {10.1055/s-2005-872223}, author = {Aher, Nilkanth G. and Pore, VS} } @article { ISI:000241967600018, title = {Design and synthesis of fluconazole/bile acid conjugate using click reaction}, journal = {Tetrahedron}, volume = {62}, number = {48}, year = {2006}, month = {NOV}, pages = {11178-11186}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, type = {Article}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

Novel fluconazole/bile acid conjugates were designed and their regioselective synthesis was achieved in very high yield via Cu(I) catalyzed intermolecular 1,3-dipolar cycloaddition. These new molecules showed good antifungal activity against Candida species. (c) 2006 Elsevier Ltd. All rights reserved.

}, keywords = {1, 2, 3-Triazole, Antifungal agent, bile acid, Click chemistry, fluconazole/bile acid conjugate}, issn = {0040-4020}, doi = {10.1016/j.tet.2006.09.021}, author = {Pore, Vandana S. and Aher, Nilkanth G. and Kumar, Manish and Shukla, Praveen K.} } @article { ISI:000253154500023, title = {Syntheis of unusual tricyclic ring systems of biological interest}, journal = {Heterocycles}, volume = {73}, number = {1}, year = {2007}, month = {DEC}, pages = {269+}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, type = {Article}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

We describe a new synthesis of tricyclic scaffolds that incorporate a fusion of triazole with 1,4-benzodiazepine utilizing intramolecular {\textquoteleft}{\textquoteleft}click{\textquoteright}{\textquoteright} chemistry.

}, keywords = {1, 2, 3-Triazole, 4-benzodiazepine, Click chemistry, nitrogen rich polycyclic hetero-system, privileged structure}, issn = {0385-5414}, author = {Mohapatra, Debendra K. and Maity, Pradip K. and Chorghade, Mukund S. and Gurjar, Mukund K.} } @article { ISI:000260776600007, title = {Functionalization of single-walled carbon nanotubes with azides derived from amino acids using click chemistry}, journal = {Journal of Nanoscience and Nanotechnology}, volume = {8}, number = {7}, year = {2008}, month = {JUL}, pages = {3351-3356}, publisher = {AMER SCIENTIFIC PUBLISHERS}, type = {Article}, address = {25650 NORTH LEWIS WAY, STEVENSON RANCH, CA 91381-1439 USA}, abstract = {

Single-walled carbon nanotubes (SWCNTs) were chemically functionalized with amino acid-based moieties. The covalent functionalization of alkyne-derived SWCNTs with well defined azides derived from amino acids was accomplished through Cu(I)-catalyzed Huisgen [3+2] dipolar cycloaddition click chemistry. Transmission electron microscopy, Raman spectroscopy, and infrared spectroscopic measurements confirmed the functionalization of SWCNTs by organic molecules derived from amino acids, and the resulting material showed some good solubility in the organic solvents such as tetrahydrofuran, CH2Cl2, and CHCl3.

}, keywords = {Amino acids, Carbon nanotubes, Click chemistry, Functionalization}, issn = {1533-4880}, doi = {10.1166/jnn.2008.109}, author = {Kumar, Indresh and Rana, Sravendra and Rode, Chandrashakher V. and Cho, Jae Whan} } @article { ISI:000265186800069, title = {Assembly of gold nanoparticles on single-walled carbon nanotubes by using click chemistry}, journal = {Journal of Nanoscience and Nanotechnology}, volume = {9}, number = {5}, year = {2009}, month = {MAY}, pages = {3261-3263}, publisher = {AMER SCIENTIFIC PUBLISHERS}, address = {25650 NORTH LEWIS WAY, STEVENSON RANCH, CA 91381-1439 USA}, abstract = {

Azide moiety-functionalized gold nanoparticles were conjugated with acetylene functionalized single-walled carbon nanotubes by employing copper-catalyzed Huisgen{\textquoteright}s [3+2] dipolar cycloaddition {\textquoteleft}click chemistry{\textquoteright} reaction. Evidences of conjunction were observed by TEM, EDX and Raman images.

}, keywords = {Carbon nanotubes, Click chemistry, Functionalization, Nanoparticles}, issn = {1533-4880}, doi = {10.1166/jnn.2009.035}, author = {Rana, Sravendra and Kumar, Indresh and Yoo, Hye Jin and Cho, Jae Whan} } @article { ISI:000264490200023, title = {Syntheis of new chiral 5,6,7,8-tetrahydrotetrazolo[1,5-a]pyrazines from alpha-amino acid derivatives following {\textquoteleft}{\textquoteleft}click{\textquoteright}{\textquoteright} chemistry}, journal = {Heterocycles}, volume = {77}, number = {2}, year = {2009}, month = {FEB}, pages = {865-872}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

An efficient and practical synthesis of new chiral fused tetrazoles have been synthesized following [3+2] cycloaddition reaction starting from alpha-amino acid derivatives.

}, keywords = {Amino acid, Click chemistry, Hypertension, Nitrogen Rich System, Tetrazole}, issn = {0385-5414}, doi = {10.3987/COM-08-S(F)121}, author = {Mohapatra, Debendra K. and Maity, Pradip K. and Ghorpade, Ravindra V. and Gurjar, Mukund K.} } @article { ISI:000278626400054, title = {Synthesis and biological evaluation of new 2-chloro-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline derivatives via click chemistry approach}, journal = {European Journal of Medicinal Chemistry}, volume = {45}, number = {7}, year = {2010}, month = {JUL}, pages = {3142-3146}, publisher = {ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER}, address = {23 RUE LINOIS, 75724 PARIS, FRANCE}, abstract = {

Synthesis of new 2-chloro-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline derivatives (4a-h) using 1,3-dipolar cycloaddition (click chemistry) reaction of 3-(azidomethyl)-2-chloro-quinoline derivatives (3a-h) with phenyl acetylene in the presence of Cu(I) catalyst has been achieved in very high yield. These molecules were evaluated in vitro for their antifungal and antibacterial activity. Most of the compounds exhibited significant antifungal and antibacterial activity against all the tested strains. (C) 2010 Elsevier Masson SAS. All rights reserved.

}, keywords = {1, 2, 2-Chloro3-formyl quinoline, 3-Triazole, Antibacterial, antifungal, Click chemistry}, issn = {0223-5234}, doi = {10.1016/j.ejmech.2010.04.002}, author = {Kategaonkar, Amol H. and Shinde, Pravin V. and Kategaonkar, Atul H. and Pasale, Sharad K. and Shingate, Bapurao B. and Shingare, Murlidhar S.} } @article { ISI:000279836400026, title = {Synthesis and characterization of polyurethane-grafted single-walled carbon nanotubes via click chemistry}, journal = {Journal of Nanoscience and Nanotechnology}, volume = {10}, number = {9}, year = {2010}, month = {SEP}, pages = {5700-5707}, publisher = {AMER SCIENTIFIC PUBLISHERS}, address = {26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA}, abstract = {

Polyurethane (PU)-grafted carbon nanotubes were synthesized by the coupling of alkyne moiety decorated single walled carbon nanotube (SWCNT) with azide moiety containing PU using Cu(I) catalyzed Huisgen [3 + 2] cycloaddition click chemistry. The azide moiety containing poly(E-caprolactone)diol was synthesized by ring-opening polymerization and further used for PU synthesis. Alkyne-functionalizion of SWCNT was completed by the reaction of p-aminophenyl propargyl ether with SWCNT using a solvent free diazotization procedure. Nuclear magnetic resonance, Fourier transform infrared, and Raman spectroscopic measurements confirmed the functionalization of SWCNT. Scanning electron microscopy and transmission electron microscopy images showed an excellent dispersion of SWCNTs, and specially debundling of SWCNTs could be observed due to polymer assisted dispersion. A quantitative grafting was successfully achieved even at high content of functional groups.

}, keywords = {Carbon nanotubes, Click chemistry, dispersion, polyurethane}, issn = {1533-4880}, doi = {10.1166/jnn.2010.2434}, author = {Rana, Sravendra and Cho, Jae Whan and Kumar, Indresh} } @article { ISI:000296273900010, title = {Click chemistry: 1,2,3-triazoles as pharmacophores}, journal = {Chemistry-an Asian Journal}, volume = {6}, number = {10, SI}, year = {2011}, month = {OCT}, pages = {2696-2718}, publisher = {WILEY-V C H VERLAG GMBH}, address = {BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY}, abstract = {

The copper(I)-catalyzed 1,2,3-triazole-forming reaction between azides and terminal alkynes has become the gold standard of {\textquoteleft}click chemistry{\textquoteright} due to its reliability, specificity, and biocompatibility. Applications of click chemistry are increasingly found in all aspects of drug discovery; they range from lead finding through combinatorial chemistry and target-templated in vitro chemistry, to proteomics and DNA research by using bioconjugation reactions. The triazole products are more than just passive linkers; they readily associate with biological targets, through hydrogen-bonding and dipole interactions. The present review will focus mainly on the recent literature for applications of this reaction in the field of medicinal chemistry, in particular on use of the 1,2,3-triazole moiety as pharmacophore.

}, keywords = {Click chemistry, Copper, Cycloaddition, pharmacophores, triazoles}, issn = {1861-4728}, doi = {10.1002/asia.201100432}, author = {Agalave, Sandip G. and Maujan, Suleman R. and Pore, Vandana S.} } @article { ISI:000290075500029, title = {Syntheses and biological evaluation of new triazole-spirochromone conjugates as inhibitors of mycobacterium tuberculosis}, journal = {Tetrahedron Letters}, volume = {52}, number = {18}, year = {2011}, month = {MAY}, pages = {2387-2389}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A series of novel 1,2,3-triazole fused spirochromone conjugates have been synthesized bearing both spirochromone moiety as well as a 1,2,3-triazole moiety. Some of the compounds have exhibited potential activity against Mycobacterium tuberculosis (virulent strain H37Rv). In particular 5e proved to be the most potent derivative exhibiting MIC = 0.78 mu g/mL. (C) 2011 Elsevier Ltd. All rights reserved.

}, keywords = {Antitubercular activity, Click chemistry, Mycobacterium tuberculosis, Spirochromones}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2011.02.099}, author = {Muthukrishnan, Murugan and Mujahid, Mohammad and Yogeeswari, P. and Sriram, D.} } @article { ISI:000303158300021, title = {Topochemical click reaction: spontaneous self-stitching of a monosaccharide to linear oligomers through lattice-controlled azide-alkyne cycloaddition}, journal = {Angewandte Chemie-International Edition}, volume = {51}, number = {18}, year = {2012}, month = {APR}, pages = {4362-4366}, publisher = {WILEY-V C H VERLAG GMBH}, address = {BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY}, keywords = {Click chemistry, green chemistry, polymerization, pseudosugars, topochemistry}, issn = {1433-7851}, doi = {10.1002/anie.201201023}, author = {Pathigoolla, Atchutarao and Gonnade, Rajesh G. and Sureshan, Kana M.} } @article { ISI:000316812800023, title = {Facile strategy for synthesis of ,-heterobifunctionalized poly (epsilon-caprolactones) and poly (methyl methacrylate)s containing {\textquoteleft}{\textquoteleft}clickable{\textquoteright}{\textquoteright} aldehyde and allyloxy functional groups using initiator approach}, journal = {Journal of Polymer Science Part A-Polymer Chemistry}, volume = {51}, number = {9}, year = {2013}, month = {MAY}, pages = {2091-2103}, publisher = {WILEY-BLACKWELL}, address = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, abstract = {

Two new initiators, namely, 4-(4-(2-(4-(allyloxy) phenyl)-5-hydroxypentane 2-yl) phenoxy)benzaldehyde and 4-(4-(allyloxy) phenyl)-4-(4-(4-formylphenoxy) phenyl) pentyl 2-bromo-2-methyl propanoate containing clickable hetero-functionalities namely aldehyde and allyloxy were synthesized starting from commercially available 4,4-bis(4-hydroxyphenyl) pentanoic acid. These initiators were utilized, respectively, for ring opening polymerization of epsilon-caprolactone and atom transfer radical polymerization of methyl methacrylate. Well-defined -aldehyde, -allyloxy heterobifunctionalized poly(epsilon-caprolactones) (Mn,GPC: 590029,000, PDI: 1.261.43) and poly(methyl methacrylate)s (Mn,GPC: 530028800, PDI: 1.191.25) were synthesized. The kinetic study of methyl methacrylate polymerization demonstrated controlled polymerization behavior. The presence of aldehyde and allyloxy functionality on polymers was confirmed by 1H NMR spectroscopy. Aldehyde-aminooxy and thiol-ene metal-free double click strategy was used to demonstrate reactivity of functional groups on polymers. (c) 2013 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013, 51, 2091-2103

}, keywords = {atom transfer radical polymerization, Click chemistry, functional polymers, ring opening polymerization}, issn = {0887-624X}, doi = {10.1002/pola.26598}, author = {Sane, Prakash S. and Tawade, Bhausaheb V. and Parmar, Indravadan and Kumari, Savita and Nagane, Samadhan and Wadgaonkar, Prakash P.} } @article { ISI:000371304100018, title = {Synthesis, biological evaluation and molecular docking of novel coumarin incorporated triazoles as antitubercular, antioxidant and antimicrobial agents}, journal = {Medicinal Chemistry Research}, volume = {25}, number = {4}, year = {2016}, month = {APR}, pages = {790-804}, publisher = {SPRINGER BIRKHAUSER}, address = {233 SPRING STREET, 6TH FLOOR, NEW YORK, NY 10013 USA}, abstract = {

A series of new coumarin-based 1,2,3-triazole derivatives were designed, synthesized and evaluated for their antitubercular activity in vitro against Mycobacterium tuberculosis H37Ra, antioxidant activity by DPPH radical scavenging assay, antimicrobial activity in vitro against three gram-positive bacteria (Staphylococcus aureus, Micrococcus luteus and Bacillus cereus) and three gram-negative bacteria (Escherichia coli, Pseudomonas fluorescens and Flavobacterium devorans as well as three fungi (Aspergillus niger, Penicillium chrysogenum and Curvularia lunata). The bioactive assay showed that some synthesized coumarin triazoles displayed comparable or even better antitubercular, antioxidant, antibacterial and antifungal efficacy in comparison with reference drugs. Furthermore, docking study has been performed against DprE1 enzyme of M. tuberculosis that showed good binding interactions. Moreover, the synthesized compounds were also analyzed for ADME properties and showed potential to build up as good oral drug candidates. New coumarin-based 1,2,3-triazole derivatives were designed, synthesized and evaluated for their antitubercular, antioxidant, antibacterial and antifungal activity. Some of the coumarin-based triazole derivatives displayed comparable or even better efficacy in comparison with reference drugs. Molecular docking study has been performed against DprE1 enzyme of Mycobacterium tuberculosis showed good binding interactions. [GRAPHICS] .

}, keywords = {1, 2, 3-Triazole, ADME prediction, Antimicrobial, Antioxidant, Antitubercular, Click chemistry, Docking study}, issn = {1054-2523}, doi = {10.1007/s00044-016-1519-9}, author = {Shaikh, Mubarak H. and Subhedar, Dnyaneshwar D. and Shingate, Bapurao B. and Khan, Firoz A. Kalam and Sangshetti, Jaiprakash N. and Khedkar, Vijay M. and Nawale, Laxman and Sarkar, Dhiman and Navale, Govinda R. and Shinde, Sandip S.} } @article {43376, title = {Clickable polyurethanes based on s- triazine ring containing aromatic diisocyanate bearing pendent alkyne group: synthesis and postmodification}, journal = {Journal of Polymer Science Part A Polymer Chemistry}, volume = {55}, year = {2017}, month = {MAR}, pages = {1008-1020}, type = {Article}, abstract = {A new s-triazine ring containing aromatic diisocyanate bearing a pendent alkyne group, namely, 2,4-bis(4-isocyanatophenoxy)-6-(prop-2-yn-1-yloxy)-1,3,5-triazine was synthesized and reacted with various diols viz., 1,10-decanediol, tetraethylene glycol and polyethylene glycols in the presence of dibutyltin dilaurate as the catalyst to obtain a series of linear polyurethanes. The selected polyurethanes possessing pendent alkyne groups were postmodified with chemically diverse azides viz., 1-(azidomethyl)benzene, 1-(azidomethyl)pyrene, and methoxy end-caped poly(ethylene glycol) azide via copper-catalysed azide-alkyne Huisgen 1,3-dipolar cycloaddition. FTIR and 1H NMR spectra indicated quantitative click reaction. UV{\textendash}vis and fluorescence spectroscopic analysis confirmed complete incorporation of pyrenyl groups indicating the formation of fluorescence active polyurethane by postmodification with 1-(azidomethyl)pyrene. TG analysis of polyurethanes indicated two stage weight loss and their thermal stability, as judged by T10 values, was governed by weight percent of urethane linkages. The water contact angle measurements revealed improved wettability with increased content of PEG either in the backbone of polyurethanes or as grafted chains. DLS and TEM studies confirmed that certain polyurethanes possessing PEG segments displayed self-assembly in aqueous solution, which was further supported by pyrene encapsulation studies using UV{\textendash}vis spectroscopy. {\textcopyright} 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 1008{\textendash}1020}, keywords = {Click chemistry, Diisocynate, Polyethelene Glycol, polyurethanes, Self- Assembly}, doi = {10.1002/pola.28461}, author = {Garg, Kavita and Chatterjee, Deepshikha and Wadgaonkar, Prakash} } @article {46072, title = {Aromatic polyesters containing pendant azido groups: synthesis, characterization, chemical modification and thermal cross-linking}, journal = {European Polymer Journal}, volume = {116}, year = {2019}, month = {JUL}, pages = {180-189}, type = {Article}, abstract = {

A partially bio-based bisphenol containing pendant azido group viz., 4,4{\textquoteright}-(5-azidopentane-2,2-diyl) diphenol (AZBPA) was synthesized starting from 4,4{\textquoteright}-bis (4-hydroxyphenyl) pentanoic acid. AZBPA was reacted with isophthaloyl chloride (IPC), terephthaloyl chloride (TPC) and a mixture of IPC/TPC (50:50 mol\%) by phase transfer-catalyzed interfacial polycondensation route to obtain aromatic polyesters containing pendant azido groups. Copolyesters containing pendant azido groups were also synthesized by polycondensation of different molar proportions of AZBPA and commercially available 4,4{\textquoteright}-(1-phenylethane-1,1-diyl) diphenol (BPA-AP) with IPC. Inherent viscosities and number average molecular weights of (co)polyesters were in the range 0.85-1.64 dL/g and 58,900-190,400, respectively, indicating the formation of reasonably high molecular weight polymers. Tough, transparent, and flexible films could be cast from chloroform solutions of these polyesters. X-Ray diffraction analysis showed that (co)polyesters were amorphous in nature. (Co)polyesters were characterized using FT-IR, H-1 NMR spectroscopy, XRD, TGA and DSC analysis. The chemical modification of a representative copolyester containing pendant azido groups was carried out quantitatively using copper-catalyzed azide-alkyne cycloaddition (CuAAC) with two alkynes viz., phenyl acetylene (PA) and ethynyl-4-nitrobenzene (ENB). Additionally, (co)polyesters containing pendant azido groups were thermally cross-linked (170 degrees C/12 h) leading to the formation of network structures based on azide to nitrene decomposition and subsequent reactions on polyester backbone. The selected cross-linked polyesters were characterized by stress-strain measurements. The cross-linked polymers exhibited higher tensile strength and Young{\textquoteright}s modulus and lower \% elongation at break compared to corresponding pristine polyesters containing pendant azido groups.

}, keywords = {Aromatic polyester, Chemical modification, Click chemistry, Pendant azido group, Thermal cross-linking}, issn = {0014-3057}, doi = {10.1016/j.eurpolymj.2019.04.019}, author = {Nagane, Samadhan S. and Verma, Savita and Tawade, V, Bhausaheb and Sane, Prakash S. and Dhanmane, Sushilkumar A. and Wadgaonkar, Prakash P.} } @article {46154, title = {Click chemistry based multicomponent approach in the synthesis of spirochromenocarbazole tethered 1,2,3-triazoles as potential anticancer agents}, journal = {Bioorganic Chemistry}, volume = {85}, year = {2019}, month = {APR}, pages = {475-486}, type = {Article}, abstract = {

A series of spirochromenocarbazole tethered 1,2,3-triazoles were synthesized via click chemistry based one-pot, five component reaction between N-propargyl isatins, malononitrile, 4-hydroxycarbazole, aralkyl halides and sodium azide using cellulose supported CuI nanoparticles (Cell-CuI NPs) as the heterogeneous catalyst. Antiproliferative activity of all the synthesized compounds was investigated against panel of cancer cell lines such as MCF-7, MDA-MB-231, HeLa, PANG-1, A-549, and THP-1. Many of the synthesized compounds exhibited good anti-proliferative activity against breast (MCF-7 and MDA-MB-231) and cervical (HeLa) cancer cells with IC50 values less than 10 mu M. In case of MCF-7 cells, among the nine compounds that showed good anti-proliferative activity, compounds 6f and 6j were found to be highly potent (IC50 , = 2.13 mu M and 4.80 mu M, respectively). In case of MDA-MB-231, three compounds (6k, 6j and 6s) showed antiproliferative activity amongst which 6k was the most potent one (IC50 = 3.78 mu M). On the other hand, in cervical cancer HeLa cells, compounds 6b, 6g, 6s and 6u showed excellent antiproliferative activity (IC50 = 4.05, 3.54, 3.83, 3.35 mu M, respectively). All the compounds were found to be nontoxic to the human umbilical vein endothelial cells (HUVECs). AO and EtBr staining and fluorescence microscopy studies of the active compounds (IC50 \< 5 mu M) suggested that these compounds induce cell death by apoptosis.

}, keywords = {1, 2, 3-Triazolylspirochromenocarbazole, Anticancer, Apoptotic assay, Click chemistry, Cytotoxicity, heterogeneous catalysis, Multicomponent synthesis}, issn = {0045-2068}, doi = {10.1016/j.bioorg.2019.01.070}, author = {Chavan, V, Pramod and Desai, V, Uday and Wadgaonkar, Prakash P. and Tapase, Savita R. and Kodam, Kisan M. and Choudhari, Amit and Sarkar, Dhiman} } @article {45482, title = {Thermally crosslinkable and chemically modifiable aromatic polyesters possessing pendant propargyloxy groups}, journal = {Journal of Polymer Science Part A-Polymer Chemistry}, volume = {57}, year = {2019}, month = {MAR}, pages = {588-597}, type = {Article}, abstract = {

New aromatic (co)polyesters containing pendant propargyloxy groups were synthesized by phase transfer-catalyzed interfacial polycondensation of 5-(propargyloxy)isophthaloyl chloride (P-IPC) and various compositions of P-IPC and isophthaloyl chloride with bisphenol A. FTIR and NMR spectroscopic data, respectively, revealed successful incorporation of pendant propargyloxy groups into (co)polyesters and formation of (co)polyesters with desired compositions. (Co)polyesters exhibited good solubility in common organic solvents such as chloroform, dichloromethane, and tetrahydrofuran and could be cast into transparent, flexible, and tough films from chloroform solution. Inherent viscosities and number average molecular weights of (co)polyesters were in the range 0.77-1.33 dL/g and 43,600-118,000 g/mol, respectively, indicating the achievement of reasonably high-molecular weights. The 10\% weight loss temperatures of (co)polyesters were in the range 390-420 degrees C, demonstrating their good thermal stability. (Co)polyesters exhibited T-g in the range 146-170 degrees C and T-g values decreased with increase in mol \% incorporation of P-IPC. The study of non-isothermal curing by DSC indicated thermal crosslinking of (co)polyesters via propargyloxy groups. The utility of pendant propargyloxy group was demonstrated by post-modification of the selected copolyester with 1-(4-azidobutyl)pyrene, 9-(azidomethyl)anthracene, and azido-terminated poly(ethyleneglycol) monomethyl ether via copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction. FTIR and H-1 NMR spectra confirmed that click reaction was quantitative. (c) 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 588-597

}, keywords = {Click chemistry, crosslinking, modification, polyesters, propargyloxy, step-growth polymerization}, issn = {0887-624X}, doi = {10.1002/pola.29297}, author = {Verma, Savita and Maher, Deepak M. and Nagane, Samadhan S. and Tawade, Bhausaheb V. and Wadgaonkar, Prakash P.} } @article {46913, title = {Enolate-mediated regioselective synthesis of 1,2,3-triazoles via azide-aldehydes or ketones [3+2]-cycloaddition reactions in aqueous phase}, journal = {Tetrahedron Letters}, volume = {61}, year = {2020}, month = {MAR}, pages = {151662}, type = {Article}, abstract = {

A synthetic route for the direct conversion of arylazides into the corresponding trizoles via phase transfer catalyst-assisted [3+2] cycloaddition reaction under basic conditions in aqueous medium is reported. This synthetic methodology, which offers high yields and excellent regioselectivity for varieties of triazoles at 100 degrees C for 24 h-48 h and this {\textquoteleft}greener{\textquoteright} synthesis constitutes an alternative to the previously reported well established click reactions. Published by Elsevier Ltd.

}, keywords = {Azides plus aldehydes or ketones, Click chemistry, triazoles, Water}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2020.151662}, author = {Tripathi, Anupam and Rode, V, Chandrashekhar and Llop, Jordi and Chavan, Subhash P. and Joshi, Sameer M.} }