@article { ISI:000293519600027,
	title = {Synthesis and characterization of bile acid-based poly beta amino esters for paclitaxel delivery},
	journal = {Journal of Applied Polymer Science},
	volume = {122},
	number = {1},
	year = {2011},
	month = {OCT},
	pages = {220-232},
	publisher = {WILEY-BLACKWELL},
	address = {COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA},
	abstract = {<p>New biodegradable poly beta amino esters were synthesized by the polymerization of Deoxycholic acid (DOCA) in all the structural planes by 1, 4 addition of Trimethylene dipiperidine (TMDP) to diacrylates of Deoxycholyl glycol, Methyl deoxycholate and Trimethylolpropane deoxycholate esters. H-1-NMR, C-13-NMR and IR studies confirmed presence of amine and Deoxycholyl units in polymers. XRD and TGA studies indicated that all the polymers were amorphous and thermostable up to 300 degrees C. DSC studies revealed glass transition temperature (T-g) in the range 70-80 degrees C. All the polymers degraded very slowly in the buffers of pH 1.1, 7.4 and 10 because of the hydrophobic nature of Deoxycholate units. These polymers also exhibited pH sensitivity due to the incorporation of amines along with Deoxycholate units in the backbone. P-Nitroaniline (PNA) release followed anomalous release kinetics. Paclitaxel (PTX) loaded nanospheres prepared from these polymers were spherical and uniform in the size range 75-250 nm and 0.4-1 mu depending upon the method of preparation. PTX loading was in the range 60-90\%, while release (up to 20-60\%) was sustained over a period of 100 h. (c) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 122: 220-232, 2011</p>},
	keywords = {bile acid, biodegradable, Nanoparticles, Paclitaxel, poly beta amino esters},
	issn = {0021-8995},
	doi = {10.1002/app.34144},
	author = {Gangwal, Jitendra J. and Kulkarni, Mohan G.}
}
@article {48810,
	title = {Aptamer tethered bio-responsive mesoporous silica nanoparticles for efficient targeted delivery of paclitaxel to treat ovarian cancer cells},
	journal = {Journal of Pharmaceutical Sciences},
	volume = {112},
	year = {2023},
	month = {MAY},
	pages = {1450-1459},
	type = {Article},
	abstract = {<p>
	Ovarian cancer is the leading cause of cancer deaths in female patients. The current therapeutics in ovarian cancer are limited and inefficient in curing the disease. To tackle this, we have synthesized tetrasulfide deriv-ative of silica doped, biodegradable, glutathione-responsive targeted mesoporous silica nanoparticles modi-fied with heterobifunctional polyethylene glycol as a linker and mucin-1 aptamer for triggered paclitaxel delivery to the ovarian cancer cells. Degradable mesoporous silica nanoparticles were synthesized by a modi-fied sol-gel method with tetraethyl orthosilicate and Bis (triethoxysilylpropyl) tetrasulfide. The degradable mesoporous silica nanoparticles were characterized by dynamic light scattering, Fourier-transform infrared spectroscopy, Scanning electron microscopy and Transmission electron microscopy. The degradable mesopo-rous silica nanoparticles had good paclitaxel encapsulation efficiency and glutathione-responsive paclitaxel release ability. The glutathione utilization assay and visual destruction observed within 10 days in transmis-sion electron microscopy images confirmed the degradation of the mesoporous silica nanoparticles in the tumor cell environment. The targeted degradable mesoporous silica nanoparticles were efficiently taken up by ovarian cancer cell lines OVACAR-3 and PA-1. The cytotoxicity of bare mesoporous silica nanoparticles evaluated on NIH-3T3 cell line showed good biocompatibility (\&gt;90\% cell viability). Significant toxicity on OVACAR-3 (IC50 25.66 nM) and PA-1 (IC50 42.93 nM) cell lines was observed when treated with paclitaxel-loaded targeted degradable mesoporous silica nanoparticles. Results of this study demonstrated that mucin-1 targeted, glutathione-responsive mesoporous silica nanoparticles loaded with paclitaxel had a significant antitumor effect on ovarian cancer cells. All these findings demonstrated that developed nano-formulation could be suitable for ovarian cancer treatment. \&amp; COPY; 2023 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.</p>
},
	keywords = {Degradable, GSH, Mesoporous silica nanoparticles, Mucin-1, Ovarian cancer, Paclitaxel, Stimuli-responsive},
	issn = {0022-3549},
	doi = {10.1016/j.xphs.2023.01.011},
	author = {Salve, Rajesh and Kumar, Pramod and Chaudhari, Bhushan P. and Gajbhiye, Virendra}
}
