@article { ISI:000366429100003,
	title = {Breaking and making of rings: a method for the preparation of 4-quinolone-3-carboxylic acid amides and the expensive drug ivacaftor},
	journal = {European Journal of Organic Chemistry},
	number = {34},
	year = {2015},
	month = {DEC},
	pages = {7433-7437},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {POSTFACH 101161, 69451 WEINHEIM, GERMANY},
	abstract = {<p>A simple and convenient method to access 4-quinolone-3-carboxylic acid amides from indole-3-acetic acid amides through one-pot oxidative cleavage of the indole ring followed by condensation (Witkop-Winterfeldt type oxidation) was explored. The scope of the method was confirmed with more than 20 examples and was successfully applied to the synthesis of the drug Ivacaftor, the most expensive drug on the market.</p>},
	keywords = {Amides, Drug design, Fused-ring systems, Oxidation, Ozonolysis},
	issn = {1434-193X},
	doi = {10.1002/ejoc.201501048},
	author = {Vasudevan, N. and Jachak, Gorakhnath R. and Reddy, D. Srinivasa}
}
@article { ISI:000380138100025,
	title = {Bronsted-acid-mediated divergent reactions of betti bases with indoles: an approach to chromeno[2,3-b]indoles through intramolecular dehydrogenative C2-alkoxylation of indole},
	journal = {European Journal of Organic Chemistry},
	number = {20},
	year = {2016},
	month = {JUL},
	pages = {3441-3448},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {POSTFACH 101161, 69451 WEINHEIM, GERMANY},
	abstract = {<p>Divergent reactions of various 1-(aminoalkyl) naphthols and 2-(aminoalkyl) phenols (commonly known as Betti bases) with indoles under Bronsted acid catalysis is reported. With the reaction strategies, one can efficiently synthesize important indole derivatives such as 3-(alpha,alpha-diarylmethyl)indoles and chromeno[2,3-b]indoles. Furthermore, we disclose here a new C-C bond-cleavage reaction, in which naphthol and phenol behave as leaving groups to produce diarylmethanes. Inexpensive reagents such as p-toluenesulfonic acid monohydrate and molecular iodine are used to catalyze the reactions. No metal catalyst is required. The starting material of the reactions, Betti bases, are easily prepared from a three-component reaction of naphthol/phenol, aldehydes, and secondary amines. The mechanisms for the reactions are established through some control experiments. Quinone methide is the key intermediate for all the reactions reported herein.</p>},
	keywords = {Betti bases, C-O bond formation, Dearylation, Fused-ring systems, nitrogen heterocycles},
	issn = {1434-193X},
	doi = {10.1002/ejoc.201600546},
	author = {Deb, Mohit L. and Pegu, Choitanya Dev and Deka, Bhaskar and Dutta, Prantu and Kotmale, Amol S. and Baruah, Pranjal K.}
}
