@article { ISI:000297470800009,
	title = {pH Sensitive graft copolymers for zero order drug release: a mechanistic analysis},
	journal = {Drug Development and Industrial Pharmacy},
	volume = {38},
	number = {1},
	year = {2012},
	month = {JAN},
	pages = {73-83},
	publisher = {INFORMA HEALTHCARE},
	address = {TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND},
	abstract = {<p>Aliphatic polyesters containing pendent unsaturation were synthesized by the polycondensation of a diol, dicarboxylic acid and glycidyl methacrylate. Grafting methacrylic acid (MAA) resulted in graft copolymers containing polyester backbone and MAA grafts. Depending on composition, the polymers swelled extensively and eroded or dissolved at near neutral pH but remained in collapsed state at acidic pH. Three representative drugs differing in solubility, viz., Diltiazem hydrochloride (DH), Indomethacin (IM) and Verapamil hydrochloride (VH) were released at constant rate from tablets made by compressing spray-dried microparticles. The release of DH at constant rate has been attributed to increase in diffusion coefficient of the drug from the swollen layer of matrix. The release of IM and VH at constant rate was governed by erosion and was enhanced in matrices which undergo dissolution. The release rate was enhanced with increasing MAA content and the frequency of grafts along the polyester backbone. Once a day dosage forms for drugs differing in solubility have been developed using a single polymer matrix which is easy to manufacture.</p>},
	keywords = {Diffusion, erosion, Graft copolymer, matrix tablets, microparticles, spray drying, sustained release},
	issn = {0363-9045},
	doi = {10.3109/03639045.2011.590991},
	author = {Muthusamy, Ramesh and Kulkarni, Mohan Gopalkrishna}
}
@article {49809,
	title = {Sustained release polyurethane microcapsules by interfacial polycondensation using aromatic diols},
	journal = {Reactive \& Functional Polymers},
	volume = {216},
	year = {2025},
	month = {NOV},
	pages = {106460},
	type = {Article},
	abstract = {<p>
	Polyurea-urethane (PUU) microcapsules prepared via interfacial polymerization have gained significant interest due to their tunable size and membrane thickness, high loading efficiency, and scalability. Although several aromatic and aliphatic diols and polyols have been used to produce PU foams and films, the use of aromatic diols to synthesize PUU MICs via interfacial polymerization is an unexplored domain due to the restricted solubility of aromatic diols in water. This report highlights the successful preparation of PUU microcapsules using an aromatic diol (benzene-1,4-dimethanol, BDM) to encapsulate dimethyl phthalate (DMP), a model insect repellent. The developed PUU microcapsules exhibited a high \% encapsulation efficiency of 92 \% and a size range of 1-20 mu m. Differential scanning calorimetry (DSC) thermograms revealed a significantly high glass transition temperature (Tg) of 143 degrees C as compared to 108 degrees C in the case of PUU MICs with aliphatic diols. Release studies confirm enhanced barrier properties for aromatic diol-based MICs as compared to aliphatic ethylene glycol-based PUU MICs, and interpretation of the release profile using the Weibull Model reveals that Fickian diffusion is the dominant mechanism in the release of DMP. These microcapsules can be used in high-performance applications such as composites, coatings, electronics, and construction.</p>
},
	keywords = {interfacial polymerization, Microencapsulation, polyurethane, sustained release},
	issn = {1381-5148},
	doi = {10.1016/j.reactfunctpolym.2025.106460},
	author = {Yadav, Prashant and Ravikumar, Aniruddha and Ambade, V. Ashootosh and Shanmuganathan, Kadhiravan}
}
