@article { ISI:000286902200016,
	title = {One-pot synthesis of 2,4,5-trisubstituted imidazoles using MoO3/SiO2, an efficient and recyclable catalyst},
	journal = {Synthetic Communications},
	volume = {41},
	number = {5},
	year = {2011},
	month = {JAN},
	pages = {PII 932996516},
	publisher = {TAYLOR \& FRANCIS INC},
	address = {325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA},
	abstract = {<p>[image omitted] A simple one-pot synthesis has been developed for the synthesis of 2,4,5-trisubstituted imidazoles using an efficient and recyclable MoO3/SiO2 solid acid catalyst by condensation of benzil or benzoin, benzaldehyde, and ammonium acetate in acetonitrile as a solvent. Using this solid catalyst, the reactions could be carried out under mild reaction conditions with very good yield of imidazoles, up to 95\%. This catalyst could be recycled very easily, which makes this methodology environmentally benign.</p>},
	keywords = {benzil, benzoin, cyclocondensation, imidazoles, MoO3, One-pot, SiO2, solid acid},
	issn = {0039-7911},
	doi = {10.1080/00397911003644415},
	author = {Bhosale, Sidhanath V. and Kalyankar, Mohan B. and Nalage, Santosh V. and Bhosale, Dattatry S. and Pandhare, Swati L. and Kotbagi, Trupti V. and Shubhangi B. Umbarkar and Dongare, Mohan K.}
}
@article { ISI:000367546300012,
	title = {Synthesis, crystal structure and in vitro DNA binding studies of combretastatin A-4 analogue},
	journal = {Croatica Chemica Acta},
	volume = {88},
	number = {3},
	year = {2015},
	month = {DEC},
	pages = {289-296},
	publisher = {CROATIAN CHEMICAL SOC},
	address = {MARULICEV TRG 19/II, 41001 ZAGREB, CROATIA},
	abstract = {<p>Synthesis of a novel Combretastatin A-4 analogue using Schiff{\textquoteright}s reaction of benzil and 4-aminoantipyrine has been achieved under solvent free conditions. The structure of compound was examined spectroscopically and confirmed from single crystal diffraction studies. The synthesized Combretastatin A-4 analogue was investigated for its DNA binding ability as the plausible mechanism for its antitumor activity. The binding propensity of the synthesized compound with calf-thymus (CT) DNA was monitored with absorption and emission spectrophotometric titrations. The calculations predict a binding constant of 7.24 x 10(4) for the complex of the synthesized compound with CT DNA which is comparable in magnitude to that of DNA binding of bactericidal drug enoxacin and typical intercalation indicator ethidium bromide (EB). Competitive binding studies of the synthesized compound with EB using fluorescence titration reveal that it displaces the DNA-bound EB and binds in intercalative mode which was further supported by circular dichroism (CD) spectroscopy. The probable site and binding energy of the compound with DNA was further theoretically investigated by molecular docking studies. The significant DNA binding ability of the synthesized Combretastatin A4 analogue as revealed from this study could be related to the anticancer activity of the Combretastatin A4.</p>},
	keywords = {benzil, bio-physical, combretastatin A-4, crystal structure, DNA binding, ethidium bromide, fluorescence, phenazones},
	issn = {0011-1643},
	doi = {10.5562/cca2662},
	author = {Rizvi, Masood Ahmad and Dangat, Yuvraj B. and Yaseen, Zahid and Gupta, Vivek and Khan, Khaliquz Zaman}
}
