@article { ISI:000312003800010,
	title = {Synthetic studies towards NG-121: diastereoselective synthesis of NG-121 methyl ether},
	journal = {Synthesis-Stuttgart},
	volume = {44},
	number = {24},
	year = {2012},
	month = {DEC},
	pages = {3797-3804},
	publisher = {GEORG THIEME VERLAG KG},
	address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY},
	abstract = {<p>Starting from unsymmetrically O-protected methyl 4-bromo-3,5-dihydroxybenzoate, a facile synthesis of the methyl ether of bioactive natural product NG-121 was accomplished in very good overall yield. The key steps were: Stille coupling reaction of the farnesyl unit with the electron-rich phenolic segment; hydroxy-directed selective epoxidation of the farnesyl chain along with concomitant phenol-driven intramolecular regio- and diastereoselective ring closure to the corresponding hydroxybenzopyran; and regioselective formylation followed by in situ reductive lactonization.</p>},
	keywords = {4-bromo-3, 5-dihydroxybenzoate, formylation, intramolecular cyclization, lactonization, NG-121 methyl ether, Stille coupling},
	issn = {0039-7881},
	doi = {10.1055/s-0032-1317544},
	author = {Singh, Mandeep and N. P. Argade}
}
@article {49275,
	title = {Strategies employing transition-metal free conditions for C-C bond formation in indoles},
	journal = {ChemistrySelect},
	volume = {9},
	year = {2024},
	month = {SEP},
	pages = {e202403280},
	type = {Review},
	abstract = {<p>
	Indole motifs are omnipresent in nature and can be found in many natural products as well as pharmaceuticals. It is for this reason synthetic transformations of indole have become a topic of interest for the organic and medicinal chemist community for decades. In this review, we have emphasized the functionalization of indoles via transition-metal-free approaches. This review touches on many aspects in different sub-sections, which gives a proposition of the tactics employed for the functionalization of indoles and an overview of the road ahead. In this review, essentially transition-metal-free conditions for C-C bond formation reactions in indoles has been explored. This review describes various approaches of functionalization at the C-2, C-3, C-4 and C-7 position of indoles which comprises arylation, alkenylation, acylation, formylation, alkylation, bisindolyl and cyclization strategies. Also, strategies incorporating N-alkylation/arylation has also been covered. image</p>
},
	keywords = {Alkylation, Arylation, formylation, Indole, transition-metal free},
	issn = {2365-6549},
	doi = {10.1002/slct.202403280},
	author = {Ghodake, Balaji M. and Paul, Sayantan and Bhattacharya, Asish K.}
}
