@article { ISI:000368065300033,
	title = {Enantioselective synthesis of spirocyclohexadienones by NHC-catalyzed formal [3+3] annulation reaction of enals},
	journal = {Angewandte Chemie-International Edition},
	volume = {55},
	number = {1},
	year = {2016},
	month = {JAN},
	pages = {268-272},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {POSTFACH 101161, 69451 WEINHEIM, GERMANY},
	abstract = {<p>The enantioselective synthesis of pyrazolone-fused spirocyclohexadienones was demonstrated by the reaction of alpha,beta-unsaturated aldehydes with alpha-arylidene pyrazolinones under oxidative N-heterocyclic carbene (NHC) catalysis. This atom-economic and formal [3+3] annulation reaction proceeds through a vinylogous Michael addition/spiroannulation/dehydrogenation cascade to afford spirocyclic compounds with an all-carbon quaternary stereocenter in moderate to good yields and excellent ee values. Key to the success of the reaction is the cooperative NHC-catalyzed generation of chiral alpha,beta-unsaturated acyl azoliums from enals, and base-mediated tandem generation of dienolate/enolate intermediates from pyrazolinones.</p>},
	keywords = {annulation reactions, asymmetric catalysis, N-heterocyclic carbenes, organocatalysis, spiro compounds},
	issn = {1433-7851},
	doi = {10.1002/anie.201507802},
	author = {Yetra, Santhivardhana Reddy and Mondal, Santigopal and Mukherjee, Subrata and Gonnade, Rajesh G. and Biju, Akkattu T.}
}
@article {49256,
	title = {The first enantioselective total synthesis of the eremophilane-type sesquiterpenoid (-)-peniroqueforin C},
	journal = {Tetrahedron Letters},
	volume = {154},
	year = {2025},
	month = {JAN },
	pages = {155386},
	type = {Article},
	abstract = {<p>
	Herein, we report the first stereoselective total synthesis of the eremophilane-type sesquiterpenoid (-)-peniroqueforin C using a chiral-pool strategy. This synthetic route features the use of readily available (S)-(+)-carvone as a chiral building block, Robinson annulation to construct the decalin system, substrate-controlled stereoselective methylation, single-step annulative construction of a tricyclic gamma-ylidene-butenolide with concomitant alkene transposition, and direct lactone-to-lactam conversion as key transformations.</p>
},
	keywords = {annulation reactions, Eremophilanes, Peniroqueforin C, Sesquiterpenoids, Total synthesis},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2024.155386},
	author = {Ingale, Sudhir R. and Vinodkumar, Ramavath and Kontham, Ravindar}
}
