@article { ISI:000320838200014,
	title = {C-3 {\textquoteleft}-endo-puckered pyrrolidine containing PNA has favorable geometry for RNA binding: novel ethano locked PNA (ethano-PNA)},
	journal = {Bioorganic \& Medicinal Chemistry},
	volume = {21},
	number = {14},
	year = {2013},
	month = {JUL},
	pages = {4092-4101},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>A novel peptide nucleic acid (PNA) analogue is designed with a constraint in the aminoethyl segment of the aegPNA backbone so that the dihedral angle beta is restricted within 60-80 degrees, compatible to form PNA:RNA duplexes. The designed monomer is further functionalized with positively charged amino-/guanidino-groups. The appropriately protected monomers were synthesized and incorporated into aegPNA oligomers at predetermined positions and their binding abilities with cDNA and RNA were investigated. A single incorporation of the modified PNA monomer into a 12-mer PNA sequence resulted in stronger binding with complementary RNA over cDNA. No significant changes in the CD signatures of the derived duplexes of modified PNA with complementary RNA were observed. (C) 2013 Elsevier Ltd. All rights reserved.</p>},
	keywords = {Antisense therapeutics, Conformationally constrained PNA, Diagnostics, Peptide nucleic acid (PNA)},
	issn = {0968-0896},
	doi = {10.1016/j.bmc.2013.05.015},
	author = {Banerjee, Anjan and Kumar, Vaijayanti A.}
}
@article {47624,
	title = {COVID-19 associated mucormycosis: evolving technologies for early and rapid diagnosis},
	journal = {3 Biotech},
	volume = {12},
	year = {2022},
	month = {JAN},
	pages = {6},
	type = {Review},
	abstract = {The post-coronavirus disease (COVID-19) mucormycosis is a deadly addition to the pandemic spectrum. Although it{\textquoteright}s a rare, aggressive, and opportunistic disease, the associated morbidity and mortality are significant. The complex interplay of factors aggravating CAM is uncontrolled diabetes, irrational and excessive use of antibiotics, steroids, and an impaired immune system. Recently, India has been witnessing a rapid surge in the cases of coronavirus disease-associated mucormycosis (CAM), since the second wave of COVID-19. The devastating and lethal implications of CAM had now become a matter of global attention. A delayed diagnosis is often associated with a poor prognosis. Therefore, the rapid and early diagnosis of infection would be life-saving. Prevention and effective management of mucormycosis depend upon its early and accurate diagnosis followed by a multimodal therapeutic approach. The current review summarizes an array of detection methods and highlights certain evolving technologies for early and rapid diagnosis of CAM. Furthermore, several potential management strategies have also been discussed, which would aid in tackling the neglected yet fatal crisis of mucormycosis associated with COVID-19.},
	keywords = {Biosensors, COVID-19, Diagnostics, Mucormycosis, Probiotics},
	issn = {2190-572X},
	doi = {10.1007/s13205-021-03080-4},
	author = {Samson, Rachel and Dharne, Mahesh}
}
