@article { ISI:000340469800044,
	title = {Mechanical downsizing of a gadolinium(iii)-based metal-organic framework for anticancer drug delivery},
	journal = {Chemistry-A European Journal},
	volume = {20},
	number = {33},
	year = {2014},
	month = {AUG},
	pages = {10514-10518},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY},
	abstract = {<p>A Gd-III-based porous metal-organic framework (MOF), Gd-pDBI, has been synthesized using fluorescent linker pDBI (pDBI=(1,4-bis(5-carboxy-1H-benzimidazole-2-yl)benzene)), resulting in a three-dimensional interpenetrated structure with a one-dimensional open channel (1.9x1.2nm) filled with hydrogen-bonded water assemblies. Gd-pDBI exhibits high thermal stability, porosity, excellent water stability, along with organic-solvent and mild acid and base stability with retention of crystallinity. Gd-pDBI was transformed to the nanoscale regime (ca. 140nm) by mechanical grinding to yield MG-Gd-pDBI with excellent water dispersibility (\&gt;90min), maintaining its porosity and crystallinity. In vitro and in vivo studies on MG-Gd-pDBI revealed its low blood toxicity and highest drug loading (12wt\%) of anticancer drug doxorubicin in MOFs reported to date with pH-responsive cancer-cell-specific drug release.</p>},
	keywords = {ball-milling, doxorubicin, drug delivery, metal-organic frameworks, nanocarriers},
	issn = {0947-6539},
	doi = {10.1002/chem.201402244},
	author = {Kundu, Tanay and Mitra, Shouvik and Patra, Prasun and Goswami, Arunava and Diaz, David Diaz and Banerjee, Rahul}
}
@article {44441,
	title = {cRGD functionalized nanocarriers for targeted delivery of bioactives},
	journal = {Journal of Drug Targeting},
	volume = {27},
	year = {2019},
	month = {FEB},
	pages = {111-124},
	type = {Article},
	abstract = {<p>The integrins αvβ3 play a very imperative role in angiogenesis and are overexpressed in endothelial cells of the tumor. Recent years have witnessed huge exploration in the field of αvβ3 integrin-mediated bioactive targeting for treatment of cancer. In these studies, the cRGD peptide has been employed extensively owing to their binding capacity to the αvβ3 integrin. Principally, RGD-based approaches comprise of antagonist molecules of the RGD sequence, drug-RGD conjugates, and most importantly tethering of the nanocarrier surface with the RGD peptide as targeting ligand. Targeting tumor vasculature or cells via cRGD conjugated nanocarriers have emerged as a promising technique for delivering chemotherapeutic drugs and imaging agents for cancer theranostics. In this review, primary emphasis has been given on the application of cRGD-anchored nanocarriers for targeted delivery of drugs, imaging agents, etc. for tumor therapy.</p>
},
	keywords = {alpha(v)beta(3) integrin receptors, cancer, cRGD, nanocarriers, targeting},
	issn = {1061-186X},
	doi = {10.1080/1061186X.2018.1473409},
	author = {Gajbhiye, Kavita Rai and Gajbhiye, Virendra and Siddiqui, Imtiaz A. and Gajbhiye, Jayant M.}
}
