@article { ISI:000341883700033,
	title = {Flexible, polymer-supported synthesis of sphingosine derivatives provides ceramides with enhanced biological activity},
	journal = {Bioorganic \& Medicinal Chemistry},
	volume = {22},
	number = {19},
	year = {2014},
	month = {OCT},
	pages = {5506-5512},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>A polymer-supported route for the synthesis of sphingosine derivatives is presented based on the C-acylation of polymeric phosphoranylidene acetates with an Fmoc-protected amino acid. The approach enables the flexible variation of the sphingosine tail through a deprotection-decarboxylation sequence followed by E-selective Wittig olefination cleavage. D-Erythro-sphingosine analogs have been synthesized by diastereoselective reduction of the keto group employing LiAlH(O-tBu)(3) as reducing agent. The effect of ceramides and keto-ceramides on the proliferation of three cancer cell lines HEP G-2, PC-12 and HL-60 was investigated and a ceramide containing an aromatic sphingosine tail was identified as being most active. (C) 2014 Elsevier Ltd. All rights reserved.</p>},
	keywords = {Apoptosis, Ceramide, Lipid rafts, Lipids, Sphingosine},
	issn = {0968-0896},
	doi = {10.1016/j.bmc.2014.07.024},
	author = {El-Dahshan, Adeeb and Al-Gharabli, Samer I. and Radetzki, Silke and Al-Tel, Taleb H. and Kumar, Pradeep and Rademann, Joerg}
}
@article { ISI:000376695700026,
	title = {Organocatalytic route to enantioselective synthesis of ceramide trafficking inhibitor HPA-12},
	journal = {Tetrahedron Letters},
	volume = {57},
	number = {22},
	year = {2016},
	month = {JUN},
	pages = {2445-2447},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>A new organocatalytic approach to the synthesis of ceramide trafficking inhibitor HPA-12 has been described starting from phenacyl bromide. The strategy involves chiral CBS reduction of gamma-ketoester and proline-catalyzed alpha-amination reaction of aldehyde followed by reduction as the key chirality inducing steps. (C) 2016 Elsevier Ltd. All rights reserved.</p>},
	keywords = {alpha-Amination, CBS reduction, Ceramide, Organocatalytic, Proline},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2016.04.087},
	author = {Lalwani, Komal G. and Sudalai, Arumugam}
}
