@article {50224,
	title = {Silica-supported orthophosphoric acid (H3PO4{\textperiodcentered}SiO2) as an environmentally friendly, heterogeneous catalyst for one-pot synthesis of 4-substituted 1,5-benzodiazepines},
	journal = {Chemistry of Heterocyclic Compounds},
	volume = {61},
	year = {2025},
	month = {OCT},
	pages = {485-490},
	type = {Article},
	abstract = {<p>
	An efficient, environmentally friendly protocol was developed for the synthesis of 4-substituted 1,5-benzodiazepines via a one-pot three-component reaction. o-Phenylenediamines, dimedone, and aldehydes were reacted in the presence of silica-supported orthophosphoric acid (H3PO4 \&amp; centerdot;SiO2) as an environmentally friendly, heterogeneous catalyst at 70 degrees C to produce 4-substituted 1,5-benzodiazepines. High to excellent yields, metal-free, environmentally friendly, reusable catalyst, and faster reactivity are the notable features of the developed protocol.</p>
},
	keywords = {4-substituted 1, 5-benzodiazepine, aldehydes, dimedone, o-Phenylenediamine, silica-supported orthophosphoric acid},
	issn = {0009-3122},
	doi = {10.1007/s10593-026-03447-6},
	author = {Kattimani, Minal S. and Khyadage, Poonam H. and Mitragotri, Satish D. and Kulkarni, Makarand A. and Wadgaonkar, Prakash P.}
}
