@article { ISI:000346134300012,
	title = {Continuous-flow meerwein arylation},
	journal = {Journal of Flow Chemistry},
	volume = {4},
	number = {4},
	year = {2014},
	month = {DEC},
	pages = {211-216},
	publisher = {AKADEMIAI KIADO RT},
	type = {Article},
	address = {PRIELLE K U 19, PO BOX 245,, H-1117 BUDAPEST, HUNGARY},
	abstract = {<p>The continuous-flow Meerwein arylation is demonstrated for a set of few aryl donors (anilines and m-aminoacetophenone) and specific radical acceptors. Homogeneous catalyst (CuBr in HBr and CuCl in HCl) was used to facilitate the reaction. The effect of parameters, viz., temperature, catalyst concentration, residence time, and concentration of the radical acceptor on the yield of the arylated product, was studied. The yield of the aryl derivative obtained by continuous-flow syntheses was always better than the respective experiments in batch mode. Flow synthesis allows easy variation in these parameters and thus allows going close to the maximum possible yields in a system where the relative rates of different reactions create a complex situation. Temperature plays a crucial role by affecting the rates as well as by governing the system homogeneity. The nitrogen bubbles generated in the reaction helped to avoid any channel blockage.</p>},
	keywords = {diazonium salt, flow chemistry, homogeneous catalyst, Meerwein arylation, micromixer, multistep synthesis},
	issn = {2062-249X},
	doi = {10.1556/JFC-D-14-00023},
	author = {Bhaya, Vinay G. and Joshi, Ramesh A. and Kulkarni, Amol A.}
}
@article {46707,
	title = {Efficient processing of reactions involving diazonium salts: meerwein arylation in an impinging-jet reactor},
	journal = {Organic Process Research \& Development},
	volume = {24},
	year = {2020},
	month = {SEP},
	pages = {1658-1664},
	type = {Article},
	abstract = {<p>This work reports a novel approach for performing high-throughput synthesis of Meerwein arylation in an impingingjet reactor. The multistep reaction was performed in a single reactor via in situ diazonium salt generation followed by Meerwein arylation. The work involves many iterations between experiments and simulations (where we integrate simulating the flow, heat transfer, and reaction simultaneously) for optimization of conditions in an inverted impinging-jet reactor. The effect of design variables viz. catalyst concentration, inlet temperature, and monomer mole ratio on the yield of the desired product was studied in detail, and the simulation results were used to plan the continuous experiments. An infrared camera was used to monitor the transient reactor temperature for steady-state analysis. The lab-scale inverted impinging-jet reactor with over 93\% isolated yield can offer a space-time yield of 277.78 tons/m(3)/day. The numbering-up of an inverted impinging-jet reactor can be an effective way for cleaner production of products through typical Meerwein arylation.</p>
},
	keywords = {computational fluid dynamics, high throughput synthesis, impinging-jet reactor, IR camera, Meerwein arylation, Numbering-up},
	issn = {1083-6160},
	doi = {10.1021/acs.oprd.0c00271},
	author = {Shukla, Chinmay A. and Atapalkar, Ranjit S. and Kulkarni, Amol A.}
}
