@article {49126,
	title = {Chloroperoxidase applications in chemical synthesis of industrial relevance},
	journal = {Biocatalysis and Biotransformation},
	volume = {41},
	year = {2023},
	month = {NOV },
	pages = {403-420},
	type = {Article},
	abstract = {<p>
	Biocatalysts can accelerate the catalysis of a chemical reaction that is difficult to synthesize with typical chemical methods. The global enzyme market size is predicted to expand at a CAGR of 6.5\% from 2021 to 2028. Enzymatic reactions are highly chemo, regio, and stereoselective and produce various fine chemicals such as drugs, agrochemicals, and fragrance molecules. Peroxidases (PO) (EC 1.11.1.x) are a large class of enzymes that play an important role in various biological processes. Chloroperoxidase (CPO, EC 1.1.1.10) is a versatile fungal haem-thiolate protein that is useful in the asymmetric synthesis of chiral building blocks and has an important role in a number of biological processes. CPO{\textquoteright}s main biological role is chlorination, although it also catalyses haem PO, catalase (CAT), and reactions similar to cytochrome P450. However, CPO performs both oxidation and stereo-specific halogenation of chemical molecules. The haem and vanadium POs are produced by Caldariomyces fumago, and Curvularia inaequalis, respectively, and are capable of halogenating the flavanones, naringenin, and hesperetin, at C-6 and C-8 in the presence of either Cl- or Br-. In this review, we discussed the various applications of CPO including synthesis of epoxides, drugs, halogenation of thymol, nitriles, the Aza-Achmatowicz reaction, and biomedical applications such as cancer and biosensors. In light of these novel features, we have provided a detailed review of CPOs and their applications in various stereoselective chemical transformations of industrial relevance.</p>
},
	keywords = {active pharmaceutical ingredients, Biotransformation, Caldariomyces fumago, chemo, Chloroperoxidase, regio, stereoselectivity},
	issn = {1024-2422},
	doi = {10.1080/10242422.2022.2107919},
	author = {Bhandari, Yogesh and Sajwan, Hemlata and Pandita, Parul and Koteswara Rao, Vamkudoth}
}
@article {49375,
	title = {Enhanced degradation of ciprofloxacin hydrochloride using hybrid advanced oxidation process of hydrodynamic cavitation and ozonation},
	journal = {Chemical Engineering \& Technology},
	volume = {47},
	year = {2024},
	month = {OCT},
	type = {Article},
	abstract = {<p>
	The degradation of ciprofloxacin hydrochloride (CFX), an extensively utilized antibiotic for bacterial infections, has been studied through the application of advanced oxidation processes (AOPs) including hydrodynamic cavitation (HC), ozonation (O3), the Fenton reaction, chemical oxidation, and hybrid AOPs such as HC/O3 and Fenton/O3. Among these, the hybrid combination of HC/O3 demonstrated the highest CFX degradation of 99.82 \% within 180 min having an initial concentration of 1000 ppm. The optimization of the HC/O3 process was conducted by varying parameters including initial concentration, pH, ozone (O3) gas flowrate, and temperature. Throughout the degradation process, CFX underwent intermediate formation, which gradually degraded over time. The hydrodynamic cavitation (HC) in combination with ozone, referred to as the HC/ozonation process, was used for the degradation of ciprofloxacin hydrochloride present in wastewater. This process underwent optimization with respect to various reaction parameters, including the initial concentration, ozone flow rate, pH level, temperature, the influence of ions, and the specific water matrix. At these optimized conditions a degradation efficiency of 99.82 \% was achieved after 180 min. image</p>
},
	keywords = {active pharmaceutical ingredients, Advance Oxidation Processes, Ciprofloxacin hydrochloride, Hybrid AOPs, Hydrodynamic cavitation},
	issn = {0930-7516},
	doi = {10.1002/ceat.202300469},
	author = {Bodawar, Narendra and Shetty, Rohit and Kamble, Sanjay and Kulkarni, Prashant}
}
