@article {47896,
	title = {Transition metal- and oxidant-free regioselective synthesis of 3,4,5-trisubstituted pyrazoles by means of [3+2] cycloaddition reactions},
	journal = {ChemistrySelect},
	volume = {7},
	year = {2022},
	month = {MAR},
	pages = {e202200605},
	type = {Article},
	abstract = {<p>
	A highly efficient regioselective synthesis of 3,4,5-trisubstituted pyrazoles via transition metal- and oxidant-free, three component [3+2] cycloaddition with thiazolidinedione chalcones, benzaldehydes and N-tosylhydrazine is described. The reaction proceeds through C-C and C-N bond formations under mild reaction conditions to produce structurally diverse polysubstituted pyrazoles in moderate to good yields.</p>
},
	keywords = {3, 4, 5-trisubstituted pyrazoles, Cycloaddition, Multicomponent reaction, Oxidant free, Regioselectivity, Transition metal free},
	issn = {2365-6549},
	doi = {10.1002/slct.202200605},
	author = {Allaka, Bhargava Sai and Basavoju, Srinivas and Gamidi, Rama Krishna}
}
@article {49497,
	title = {Continuous flow β-zeolite catalysed regioselective alkylation of naphthols using alcohols for synthesis of peroxynaphthalen-2(1H)-one, Azidonaphthalen-2(1H)-one and Fluoronaphthalen-2(1H)-one derivatives},
	journal = {Asian Journal of Organic Chemistry},
	volume = {14},
	year = {2025},
	month = {APR},
	type = {Article},
	abstract = {<p>
	Functionalized naphthols are prominent scaffolds in organic synthesis and materials chemistry. Herein, we demonstrated continuous flow alkylation of alpha- and beta-naphthols by using various primary and secondary benzylic alcohols in the presence of environmentally benign granular beta-zeolite as a reusable catalyst. For a variety of beta-naphthols, the respective alkylated products with good regioselectivity were obtained in high yields under mild reaction conditions. This protocol proceeded via the classical Friedel-Crafts type alkylation process and generated stable carbocations as intermediates. Applying this protocol, versatile naphthol derivatives have been synthesized using primary and secondary benzylic alcohols (50 and 44 examples in batch and continuous flow process, respectively), with good yields. Key advantages of this process includes rapid and efficient transformation, facilitates gram-scale synthesis, and generates water as the sole by-product. The most significant advantage is the continuous reusability of granular beta-zeolite, which further emphasizes the sustainability of the method. The application of alkylated naphthols for quaternary functionalization was demonstrated through peroxidation, azidation, and halogenation reactions under the continuous flow module, which yielded the respective peroxynaphthalen-2(1H)-one, azidonaphthalen-2(1H)-one and fluoronaphthalen2(1H)-one derivatives.</p>
},
	keywords = {continuous flow, Multigram Synthesis, Reusable beta-zeolite, Sustainable Appraoch, Transition metal free},
	issn = {2193-5807},
	doi = {10.1002/ajoc.202400658},
	author = {Londhe, Gokul and Bokade, Vijay and Gnanaprakasam, Boopathy}
}
