@article {47808,
	title = {Inter-relationship of Histone Deacetylase-6 with Tau-cytoskeletal organization and remodeling},
	journal = {European Journal of Cell Biology},
	volume = {101},
	year = {2022},
	month = {APR},
	pages = {151202},
	type = {Article},
	abstract = {Cytoskeletal elements are the key players in cellular integrity, structure, signalling and migration. Each cytoskeletal element comprises of properties with respect to its structure and stability, which serve a specific array of functions. These structures are highly dynamic and regulated by modulation via direct interaction or post-translational modifications. HDAC6 is a cytoplasmic deacetylase known to regulate a wide range of cellular functions either through its deacetylase activity or direct interaction via its C-terminal ZnF UBP domain. HDAC6 has been widely studied for its role in aggresome formation, which acts as a protective mechanism upon protein aggregation. HDAC6 is known to play a critical role in the regulation of cytoskeletal elements-microtubules and actin filaments. This review summarizes the regulatory role of HDAC6 in cytoskeletal remodeling and dynamics of neuronal cells and its significance in neurodegenerative diseases.},
	keywords = {Actin, Cell migration, Cytoskeleton remodeling, HDAC6, Microtubules, Podosomes, ZnF UBP},
	issn = {0171-9335},
	doi = {10.1016/j.ejcb.2022.151202},
	author = {Abhishek Ankur Balmik and Subashchandrabose Chinnathambi}
}
