@article {46415,
	title = {C-H functionalization of indoles by 3d transition-metal catalysis},
	journal = {Asian Journal of Organic Chemistry},
	year = {2019},
	month = {DEC},
	type = {Review; Early Access},
	abstract = {<p>Over the past decade, the use of 3d transition metal for the regioselective C-H bond functionalization of indoles has significantly increased. Particularly, advances in manganese, iron, cobalt, nickel and copper catalysis have demonstrated the selective C(2)-H and C(3)-H arylation, alkenylation, alkynylation and alkylation to a greater extent. Similarly, the C-O and C-N bond-forming reactions are manifested via direct C-H bond activation by these earth-abundant metals. The emergence of 3d metals in selective functionalization of the biologically relevant indoles and related heteroarenes would make this protocol more attractive for practical applications. Herein, we provide a brief overview of 3d transition metal-catalyzed (mostly Mn, Fe, Co, Ni and Cu) C-H functionalization of indoles and related heteroarenes.</p>
},
	keywords = {3d transition metal, C-H functionalization, Indole, indoline},
	issn = {2193-5807},
	doi = {10.1002/ajoc.201900554},
	author = {Jagtap, Rahul A. and Punji, Benudhar}
}
@article {47999,
	title = {Manganese-catalyzed C(sp(2))-H alkylation of indolines and arenes with unactivated alkyl bromides},
	journal = {Chemistry-an Asian Journal},
	volume = {17},
	year = {2022},
	month = {MAY},
	pages = {e202200103},
	type = {Article},
	abstract = {<p>
	Selective C(sp(2))-H bond alkylation of indoline, carbazole and (2-pyridinyl)arenes with unactivated alkyl bromides is achieved using MnBr2 catalyst in the absence of an external ligand. The alkylation uses a simple LiHMDS base and avoids the necessity of Grignard reagent, unlike other Mn-catalyzed C-H functionalization. This reaction proceeded either through a five- or a less-favored six-membered metallacycle, and tolerated diverse functionalities, including alkenyl, alkynyl, silyl, aryl ether, pyrrolyl, indolyl, carbazolyl and alkyl bearing fatty alcohol and polycyclic-steroid moieties. Alkylation follows a single electron transfer (SET) pathway involving 1e oxidative addition of alkyl bromide and a rate-limiting C-H metalation.</p>
},
	keywords = {Alkylation, C-H activation, indoline, ligand-free, manganese},
	issn = {1861-4728},
	doi = {10.1002/asia.202200103},
	author = {Verma, Suryadev K. and Punji, Benudhar}
}
