@article { ISI:000296273900010,
	title = {Click chemistry: 1,2,3-triazoles as pharmacophores},
	journal = {Chemistry-an Asian Journal},
	volume = {6},
	number = {10, SI},
	year = {2011},
	month = {OCT},
	pages = {2696-2718},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY},
	abstract = {<p>The copper(I)-catalyzed 1,2,3-triazole-forming reaction between azides and terminal alkynes has become the gold standard of {\textquoteleft}click chemistry{\textquoteright} due to its reliability, specificity, and biocompatibility. Applications of click chemistry are increasingly found in all aspects of drug discovery; they range from lead finding through combinatorial chemistry and target-templated in vitro chemistry, to proteomics and DNA research by using bioconjugation reactions. The triazole products are more than just passive linkers; they readily associate with biological targets, through hydrogen-bonding and dipole interactions. The present review will focus mainly on the recent literature for applications of this reaction in the field of medicinal chemistry, in particular on use of the 1,2,3-triazole moiety as pharmacophore.</p>},
	keywords = {Click chemistry, Copper, Cycloaddition, pharmacophores, triazoles},
	issn = {1861-4728},
	doi = {10.1002/asia.201100432},
	author = {Agalave, Sandip G. and Maujan, Suleman R. and Pore, Vandana S.}
}
@article { ISI:000362588700016,
	title = {Alumina-supported copper iodide: an efficient and recyclable catalyst for microwave-assisted synthesis of 1,4-disubstituted 1,2,3-triazoles via three-component reaction in water},
	journal = {Asian Journal of Organic Chemistry},
	volume = {4},
	number = {9},
	year = {2015},
	month = {SEP},
	pages = {943-951},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {POSTFACH 101161, 69451 WEINHEIM, GERMANY},
	abstract = {<p>A one-pot procedure for the synthesis of 1,4-disubstituted 1,2,3-triazoles by a three-component reaction of allyl or benzyl halides, sodium azide, and terminal alkynes over a neutral alumina-supported copper iodide catalyst has been developed. The products were isolated by simple filtration followed by washing of the catalyst with acetone. The products were obtained in almost pure form in up to 98\% yield (TON 495). The catalyst can be recycled for more than eight subsequent reactions. The halides are directly converted into triazoles via in situ formation of azides and thus handling of hazardous azides can be avoided. The broad scope of this protocol is shown by the synthesis of a variety of diversely substituted 1,2,3-triazoles and also two-component azide-alkyne click reaction. The key features of this procedure are the use of water as a solvent, recyclability of the catalyst up to eight runs without appreciable loss of activity, and high yields of products. The catalyst has been fully characterized by FTIR, solid-state NMR and EDX spectroscopy, ESEM, TGA, and XRD.</p>},
	keywords = {1, 2, 3-triazoles, 4, copper(I) iodide, Cycloaddition, disubstituted 1, Microwave chemistry, supported catalysts},
	issn = {2193-5807},
	doi = {10.1002/ajoc.201500189},
	author = {Agalave, Sandip G. and Pharande, Shrikant G. and Gade, Swapna M. and Pore, Vandana S.}
}
