@article {42743,
	title = {Cobalt-catalyzed C{\textendash}H bond functionalizations with aryl and alkyl chlorides},
	journal = {Chemistry - A European Journal},
	volume = {19},
	year = {2013},
	month = {AUG},
	pages = {10605{\textendash}10610},
	abstract = {<p>Inexpensive cobalt catalysts derived from N-heterocylic carbenes (NHC) allowed efficient catalytic C[BOND]H bond arylations on heteroaryl-substituted arenes with widely available aryl chlorides, which set the stage for the preparation of sterically hindered tri-ortho-substituted biaryls. Likewise, challenging direct alkylations with β-hydrogen-containing primary and even secondary alkyl chlorides proceeded on pyridyl- and pyrimidyl-substituted arenes and heteroarenes. The cobalt-catalyzed C[BOND]H bond functionalizations occurred efficiently at ambient reaction temperature with excellent levels of site-selectivities and ample scope. Mechanistic studies highlighted that electron-deficient aryl chlorides reacted preferentially, while the arenes kinetic C[BOND]H bond acidity was found to largely govern their reactivity.</p>},
	doi = {10.1002/chem.201301409},
	author = {Punji, Benudhar and Song, Weifeng and Shevchenko, Grigory A. and Ackermann, Lutz}
}
