@article { ISI:000360597400020,
	title = {Synthesis of (+/-) debenzoyl analogs of norsampsones as potential anticancer agents},
	journal = {Tetrahedron Letters},
	volume = {56},
	number = {37},
	year = {2015},
	month = {SEP},
	pages = {5235-5237},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>Synthesis of (+/-) debenzoyl analogs of norsampsones 1 and 2 is reported starting from commercially available 1,3-cyclohexadione in six steps with overall yields of 37\% and 36\%, respectively. Compounds 1 and 2 were tested for their anticancer activity and showed moderate anticancer activity against HeLa cell lines. (C) 2015 Elsevier Ltd. All rights reserved.</p>},
	keywords = {Acylphloroglucinols, Anticancer, Debenzoyl, Norsampsones},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2015.07.057},
	author = {Jadhav, Amol R. and Thombal, Raju S. and Nigam, Preeti and Jadhav, Vrushali H.}
}
@article {49276,
	title = {Alternative synthetic route for the pharmacophore of anticancer agent: triazolopyridazine derivative},
	journal = {Tetrahedron Letters},
	volume = {146},
	year = {2024},
	month = {AUG},
	pages = {155193},
	type = {Article},
	abstract = {<p>
	ATAD2 has received attention as one of the potential oncogene with tumor-promoting aspects in many malignancies. ATAD2 is a highly conserved bromodomain family protein that exerts its biological functions by mainly AAA ATPase and bromodomain. Several small molecule inhibitors have been described in the literature. AZ13824374 (1) recently reported by Holt and co-workers showed promising in vitro (bio-chemical, cellular) and antiproliferative activity in range of breast cancer models. In this work, we described scalable synthetic route for triazolopyridazine derivative (2), a key intermediate of AZ13824374 (1) without using CO in the process. Triazolopyridazine helps to attain the bioactive conformation for AZ13824374 (1) through its crucial interaction with Tyr 1021 of ATAD2. Additionally, triazolopyridazine is extensively used as an intermediate for anticancer agents. This encouraged us to develop cost-effective and scalable process for it.</p>
},
	keywords = {Alternative process, Anticancer, Triazolopyridazine},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2024.155193},
	author = {Karche, Ranjit S. and Bankar, Shubham R. and Jadhav, Vrushali H.}
}
