@article {43380, title = {Application of nanotechnology for detection and decontamination of organophosphorus pesticides and warfare agents}, journal = {Nanotrends}, volume = {8}, year = {2010}, month = {JUN}, pages = {1-17}, author = {Nigam, Preeti} } @article {43379, title = {Aptamer functionalized multifunctional fluorescent nanotheranostic platform for pancreatic cancer}, journal = {Journal of Nanopharm Drug Delivery}, year = {2014}, month = {DEC}, abstract = {This study explores the potential of aptamer functionalized and fluorescent silver nanoparticles (AgNPs) labeled human serum albumin nanoparticles for drug delivery and bioimaging. Nanotechnology is certainly the most promising research arena in recent years and different fields of biotechnology, medicine and agricultural have been deeply benefited by the enormous advantages of nanotechnology. In recent years, synthesis of nanoparticles via eco-friendly methods has attained a lot of interest and silver nanoparticles are synthesized extensively due to their size tunable properties and vast applicability in different areas. In this study we have explored green synthesized fluorescent silver nanoparticles as a novel bioimaging agent for pancreatic cancer. Capsaicin, a plant phytochemical found in red chilli pepper was encapsulated in aptamer MUC-1 coupled albumin nanoparticles and it was observed that the nanoformulation significantly enhanced the bioavailability and sustained release property of the drug to pancreatic cancer cells in-vitro. Meanwhile AgNPs mediated excellent bioimaging has enhanced the efficacy of our system as drug delivery vehicle.}, doi = {10.1166/jnd.2014.1070}, author = {Nigam, Preeti and Waghmode, Shobha A. and Yeware, Amar M. and Nawale, Laxman U. and Dagde, Priyanka and Dudhane, Amol and Sarkar, Dhiman} } @article { ISI:000336072400003, title = {Graphene quantum dots conjugated albumin nanoparticles for targeted drug delivery and imaging of pancreatic cancer}, journal = {Journal of Materials Chemistry B}, volume = {2}, number = {21}, year = {2014}, month = {JUN}, pages = {3190-3195}, publisher = {ROYAL SOC CHEMISTRY}, address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND}, abstract = {

Pancreatic cancer is considered to be the deadliest of all cancers due to its poor prognosis and resistance to conventional therapies. In this study, the potential of hyaluronic acid functionalized and green fluorescent graphene quantum dot (GQD)-labeled human serum albumin nanoparticles for pancreatic cancer specific drug delivery and bioimaging was explored. GQDs with tunable fluorescence properties and biocompatibility have attracted much more interest in recent years as compared to their metal semiconductor counterparts. We adopted lawsone (2-hydroxy-1,4-naphthoquinone) as a novel reducing agent for the synthesis of quantum dots and, in addition to excellent fluorescence of the synthesized GQDs, a good quantum yield of similar to 14\% was also obtained. Gemcitabine, the most preferred drug for pancreatic cancer treatment, was encapsulated in albumin nanoparticles, and it was observed that our nanoformulation significantly enhanced the bioavailability and sustained release property of the drug to pancreatic cancer cells in vitro. Moreover, the GQD-mediated bioimaging was excellent and enhanced the efficacy of our system as a drug delivery vehicle.

}, issn = {2050-750X}, doi = {10.1039/c4tb00015c}, author = {Nigam, Preeti and Waghmode, Shobha and Louis, Michelle and Wangnoo, Shishanka and Chavan, Pooja and Sarkar, Dhiman} } @article {42975, title = {Multifunctional silica nanoparticles for pancreatic cancer specific drug delivery and bioimaging}, journal = {Journal of Chemistry \& Applied Biochemistry}, volume = {2}, year = {2015}, month = {JUN}, abstract = {

Mesoporous silica nanoparticles (MSN) have attracted increasing interest as drug carriers due to their biocompatibility and robustness. In this analysis we explored the potential of MSN as nanotheranostic platform for pancreatic cancer specific drug delivery and bioimaging. Pancreatic cancer is the most fatal cancer and due to its high mortality and low prognosis it is imperative to develop new methods for early diagnosis and therapy of this cancer. Though traditionally organic dyes, quantum dots and fluorescent agents are used for bioimaging but here we have utilized graphene quantum dots (GQDs) for bioimaging due to their superior biocompatibility and fluorescence properties. MSN were loaded with gemcitabine; the most preferred drug for pancreatic cancer. MSN and GQDs were characterized by SEM, TEM, FT-IR etc and the efficacy of nanoformulation was determined by MTT assay.

}, author = {Nigam, Preeti and Sarkar, Dhiman} } @article { ISI:000360597400020, title = {Synthesis of (+/-) debenzoyl analogs of norsampsones as potential anticancer agents}, journal = {Tetrahedron Letters}, volume = {56}, number = {37}, year = {2015}, month = {SEP}, pages = {5235-5237}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

Synthesis of (+/-) debenzoyl analogs of norsampsones 1 and 2 is reported starting from commercially available 1,3-cyclohexadione in six steps with overall yields of 37\% and 36\%, respectively. Compounds 1 and 2 were tested for their anticancer activity and showed moderate anticancer activity against HeLa cell lines. (C) 2015 Elsevier Ltd. All rights reserved.

}, keywords = {Acylphloroglucinols, Anticancer, Debenzoyl, Norsampsones}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2015.07.057}, author = {Jadhav, Amol R. and Thombal, Raju S. and Nigam, Preeti and Jadhav, Vrushali H.} } @inbook {47306, title = {Nanorobots for in vivo monitoring: the future of nano-implantable devices}, booktitle = {Nanobiomaterial Engineering }, year = {2020}, pages = {227-252}, publisher = {Springer}, organization = {Springer}, abstract = {

Innovation is important for the healthcare system advancement, in order to continue delivering the high-quality care at an affordable cost to the society. It can be achieved by nonconventional thinking, tapping into creative minds, and extensive collaborative work to make better use of existing facilities and designing new technologies. Nanorobotics is such an innovation that can revolutionize the current face of medicine and biomedical sciences with their state-of-the-art technology. Improved outcomes of nanorobots-based treatments for diabetes, drug delivery for pancreatic and ovarian cancer, and laparoscopic treatment of skin cancer have already been reported. This book chapter will cover the recent advancements of this emerging field with their biomedical applications.

}, doi = {10.1007/978-981-32-9840-8_12}, author = {Gandhi, Mamta and Nigam, Preeti} }