@article { ISI:000310467600030,
	title = {Achieving molecular stability of racemic 4-O-benzyl-myo-inositol-1,3,5-orthoformate through crystal formation},
	journal = {Crystengcomm},
	volume = {14},
	number = {23},
	year = {2012},
	month = {AUG},
	pages = {8010-8016},
	publisher = {ROYAL SOC CHEMISTRY},
	address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND},
	abstract = {<p>Molecular stability of racemic 4-O-benzyl-myo-inositol-1,3,5-orthoformate, an early intermediate during the synthesis of phosphoinositols, depends on the phase in which it is stored. This orthoformate is stable when stored in the crystalline form or as solution in common organic solvents. The former has eluded chemists since the preparation of this benzyl ether two decades ago. The difficulty in obtaining crystals of this orthoformate is due to the cleavage of the orthoformate moiety during storage in the gummy state. Dimorphs (form I and form II) of crystalline racemic 4-O-benzyl-myo-inositol-1,3,5-orthoformate, were obtained when the gummy sample was stored over extended periods of time. Form I crystals could be obtained consistently, by crystallization of a frozen (-20 degrees C) solid sample, from a solution of dichloromethane- light petroleum. The two crystal forms display dissimilar patterns of hydrogen bonding and molecular assembly in the solid-state.</p>},
	issn = {1466-8033},
	doi = {10.1039/c2ce26199e},
	author = {Sardessai, Richa and Krishnaswamy, Shobhana and Shashidhar, Mysore S.}
}
@article {46384,
	title = {Acyl-transfer reactions in molecular crystals: reactivity correlation with crystal structure},
	journal = {Acta Crystallographica A-Foundation and Advances},
	volume = {70},
	year = {2014},
	month = {APR},
	pages = {C771},
	type = {Meeting Abstract},
	keywords = {crystal engineering, intermolecular interactions, solid-state reactions},
	issn = {2053-2733},
	author = {Gonnade, Rajesh G. and Shashidhar, Mysore S.}
}
@article {47669,
	title = {Access to enantiomeric organic compounds with potential for synthesis via racemic conglomerates: inositol derivatives as a case in point},
	journal = {Crystal Growth \& Design},
	volume = {21},
	year = {2021},
	month = {JUL},
	pages = {3786-3797},
	type = {Article},
	abstract = {The crystal structure database was used to identify inositol derivatives that could be crystallizing as racemic conglomerates. Among the six racemic inositol derivatives identified, racemic 4-O-tosyl-6-O-benzyl-myo-inositol-1,3,5-orthoformate (A) was found to be a true conglomerate and was resolved on the multigram scale by the preferential crystallization technique. This resolution procedure does not require the use of any enantiomeric resolving agent. The resolved enantiomers of A are useful for the synthesis of natural and unnatural enantiomeric derivatives of inositol, since they carry orthogonal hydroxy protecting groups. Racemic 4-O-methanesulfonyl-myo-inositol-1,3,5-orthoformate (B) on crystallization from common organic solvents generally yielded racemic twin crystals, while in the presence of structural analogs as additives, they yielded true racemic crystals. A comparison of the crystal structures of the true racemate, twinned crystal and crystal of one of the enantiomers of B, revealed the reasons for the formation of polymorphic (twin) crystals. Such instances are relatively rarely encountered but nevertheless shed light on our understanding of polymorphism and twinning of crystals.},
	issn = {1528-7483},
	doi = {10.1021/acs.cgd.1c00126},
	author = {Patil, Nivedita T. and Patil, Madhuri T. and Sarkar, Nitai and Gonnade, Rajesh G. and Shashidhar, Mysore S.}
}
