@article {46393,
	title = {Pharmaceutical solids in crystal engineering},
	journal = {Acta Crystallographica A-Foundation and Advances},
	volume = {70},
	year = {2014},
	month = {MAY},
	pages = {C12},
	type = {Meeting Abstract},
	keywords = {cocrystals, crystal engineering, Supramolecular synthon},
	issn = {2053-2733},
	author = {Nangia, Ashwini}
}
@article {45740,
	title = {Mechanochemical synthesis of N-salicylideneaniline: thermosalient effect of polymorphic crystals},
	journal = {IUCRJ},
	volume = {4},
	year = {2017},
	month = {MAY},
	pages = {243-250},
	type = {Article},
	abstract = {<p>Polymorphs of the dichloro derivative of N-salicylideneaniline exhibit mechanical responses such as jumping (Forms I and III) and exploding (Form II) in its three polymorphs. The molecules are connected via the amide N-H center dot center dot center dot O dimer synthon and C-Cl center dot center dot center dot O halogen bond in the three crystal structures. A fourth high-temperature Form IV was confirmed by variable-temperature single-crystal X-ray diffraction at 180 degrees C. The behaviour of jumping exhibited by the polymorphic crystals of Forms I and III is due to the layered sheet morphology and the transmission of thermal stress in a single direction, compared with the corrugated sheet structure of Form II such that heat dissipation is more isotropic causing blasting. The role of weak C-Cl center dot center dot center dot O interactions in the thermal response of molecular crystals is discussed.</p>},
	keywords = {crystal design, crystal engineering, Halogen bonding, hydrogen bonding, intermolecular interactions, materials science, mechanochemistry, polymorphism},
	issn = {2052-2525},
	doi = {10.1107/S2052252517004043},
	author = {Mittapalli, Sudhir and Perumalla, D. Sravanakumar and Nangia, Ashwini}
}
@article {46069,
	title = {Supramolecular synthon hierarchy in sulfonamide cocrystals with syn-amides and N-oxides},
	journal = {IUCRJ},
	volume = {6},
	year = {2019},
	month = {JUL},
	pages = {751-760},
	type = {Article},
	abstract = {<p>Sulfonamide drugs are well known antibacterial and antimicrobial molecules for pharmaceutical development. Building a library of suitable supramolecular synthons for the sulfonamide functional group and understanding their crystal structures with partner coformer molecules continues to be a challenge in crystal engineering. Although a few sulfonamide cocrystals with amides and N-oxides have been reported, the body of work on sulfonamide synthons is limited compared with those that have carboxylic acids and carboxamides. To address this structural gap, the present work is primarily focused on sulfonamide-lactam and sulfonamide-syn-amide synthons with drugs such as celecoxib, hydrochlorothiazide and furosemide. Furthermore, the electrostatic potential of previously reported cocrystals has been recalculated to show that the negative electrostatic potential on the lactam and syn-amide O atom is higher compared with the charge on carboxamide and pyridine N-oxide O atoms. The potential of sulfonamide molecules to form cocrystals with syn-amides and lactams are evaluated in terms of the electrostatic potential energy for the designed supramolecular synthons.</p>
},
	keywords = {cocrystals, crystal engineering, sulfonamides, supramolecular synthons, syn-amides},
	issn = {2052-2525},
	doi = {10.1107/S2052252519005037},
	author = {Bolla, Geetha and Nangia, Ashwini}
}
