@article { ISI:000306547300013,
	title = {Microstructural elucidation of self-emulsifying system: effect of chemical structure},
	journal = {Pharmaceutical Research},
	volume = {29},
	number = {8},
	year = {2012},
	month = {AUG},
	pages = {2180-2188},
	publisher = {SPRINGER/PLENUM PUBLISHERS},
	address = {233 SPRING ST, NEW YORK, NY 10013 USA},
	abstract = {<p>Self-emulsifying systems (SES) emulsify spontaneously to produce fine oil-in-water emulsion when introduced into aqueous phase. The self-emulsification process plays an important role during formation of emulsion. The objective of current work was to understand and explore the inner structuration of SES through controlled hydration and further to study the influence of additive on the same which ultimately governs performance of final formulation in terms of droplet size. Droplet size of final formulations containing structural analogues of ibuprofen was determined. Microstructural properties of intermediate hydrated regimes of SES were investigated using techniques such as small angle X-ray scattering, differential scanning calorimetry and rheology. The current work established inverse relationship between droplet size of the formulations containing structural analogues of ibuprofen and their Log P values. Microstructural analysis of intermediate hydrated regimes of the prepared samples showed formation of local lamellar structure. Structural analogues of ibuprofen significantly altered microstructure of lamellae which was well correlated with the droplet size of final formulations. In vitro drug release study showed increase in dissolution rate of lipophillic drugs when formulated as SES. The current work emphasizes the fact that tailor-made formulations can be prepared by controlling the properties of intermediate regimes.</p>},
	keywords = {emulsion, flurbiprofen, ibuprofen, ketoprofen, lamellar structure, self-emulsifying system, structural analogues},
	issn = {0724-8741},
	doi = {10.1007/s11095-012-0746-0},
	author = {Patil, Sharvil S. and Venugopal, Edakkal and Bhat, Suresh K. and Mahadik, Kakasaheb R. and Paradkar, Anant R.}
}
@article { ISI:000363839500017,
	title = {Exploring microstructural changes in structural analogues of ibuprofen-hosted in situ gelling system and its influence on pharmaceutical performance},
	journal = {AAPS Pharmscitech},
	volume = {16},
	number = {5},
	year = {2015},
	month = {OCT},
	pages = {1153-1159},
	publisher = {SPRINGER},
	address = {233 SPRING ST, NEW YORK, NY 10013 USA},
	abstract = {<p>The present work explores inner structuration of in situ gelling system consisting of glyceryl monooleate (GMO) and oleic acid (OA). The system under study involves investigation of microstructural changes which are believed to govern the pharmaceutical performance of final formulation. The changes which are often termed mesophasic transformation were analysed by small angle Xray scattering (SAXS), differential scanning calorimetry (DSC), rheology and plane polarised light (PPL) microscopy. The current work revealed transformation of blank system from W/O emulsion to reverse hexagonal structure upon addition of structural analogues of ibuprofen. Such transformations are believed to occur due to increased hydrophobic volume within system as probed by SAXS analysis. The findings of SAXS studies were well supported by DSC, rheology and PPL microscopy. The study established inverse relationship between log P value of structural analogues of ibuprofen and the degree of binding of water molecules to surfactant chains. Such relationship had pronounced effect on sol-gel transformation process. The prepared in situ gelling system showed sustained drug release which followed Higuchi model.</p>},
	keywords = {flurbiprofen, hexagonal phase, ibuprofen, ketoprofen, liquid crystal, sustained drug release},
	issn = {1530-9932},
	doi = {10.1208/s12249-015-0308-y},
	author = {Patil, Sharvil S. and Venugopal, Edakkal and Bhat, Suresh K. and Mahadik, Kakasaheb R. and Paradkar, Anant R.}
}
