@article {42900,
	title = {Repurposing of a drug scaffold: identification of novel sila analogues of rimonabant as potent antitubercular agents},
	journal = {European Journal of Medicinal Chemistry},
	volume = {122},
	year = {2016},
	month = {OCT},
	pages = {723-730},
	abstract = {<p>The structural similarity between an MmpL3 inhibitor BM212, and a cannabinoid receptor modulator rimonabant, prompted us to investigate the anti-tubercular activity of rimonabant and its analogues. Further optimization, particularly through incorporation of silicon into the scaffold, resulted in new compounds with significant improvement in anti-tubercular activity against Mycobacterium tuberculosis (H37Rv). The sila analogue 18a was found to be the most potent antimycobacterial compound (MIC, 31 ng/mL) from this series with an excellent selectivity index. (C) 2016 Elsevier Masson SAS. All rights reserved.</p>},
	doi = {10.1016/j.ejmech.2016.07.009},
	author = {Ramesh, Remya and Shingare, Rahul D. and Kumar, Vinod and Anand, Amitesh and Swetha, B. and Veeraraghavan, Sridhar and Viswanadha, Srikant and Ummanni, Ramesh and Gokhale, Rajesh S. and Reddy, D. Srinivasa}
}
@article { ISI:000374876700814,
	title = {Repurposing of old drugs: identification of novel sila analogues of rimonabant as potent antitubercular agents},
	journal = {International Journal of Infectious Diseases},
	volume = {45},
	number = {1},
	year = {2016},
	month = {APR},
	pages = {407-408},
	publisher = {ELSEVIER SCI LTD},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND},
	issn = {1201-9712},
	doi = {10.1016/j.ijid.2016.02.870},
	author = {Ramesh, R. and Shingare, R. and Anand, Amitesh and Veeraraghavan, S. and Viswanadha, S. and Ummanni, R. and Gokhale, R. and Reddy, D. S.}
}
