@article { ISI:000300606400030,
	title = {Green approach towards size controlled synthesis of biocompatible antibacterial metal nanoparticles in aqueous phase using lysozyme},
	journal = {Current Nanoscience},
	volume = {8},
	number = {1},
	year = {2012},
	month = {FEB},
	pages = {130-140},
	publisher = {BENTHAM SCIENCE PUBL LTD},
	address = {EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES},
	abstract = {<p>Inspired by array of proteins present in nature, we choose lysozyme (hen egg protein) as a model system to synthesize nanoparticles of noble metals to understand the mechanism of interaction as well as to use them for potential applications such as potent antibacterial agents. Lysozyme is a very well studied biomolecule containing aromatic amino acids like tryptophan and tyrosine. Tyrosine has phenoxy group which is considered to be responsible for interacting with the metal ions. Lysozyme can be suitably modified by treatment with N-bromosuccinimide/N-acetylimidazole to obtain tight control over size distribution of nanoparticles. Here we report the direct synthesis of nanocrystals of gold and silver at controlled pH and light conditions without using any known reducing agents. Out of these, synthesis of gold nanoparticles is assisted by the presence of low concentration of Ag+ ions through the galvanic exchange. It is remarkable to note that the structure of protein is not changed drastically as seen by the FTIR studies. As-synthesized lysozyme capped nanoparticles prepared by this method are biocompatible and retain antibacterial property.</p>},
	keywords = {Antibacterial, Biocompatible, Gold, lysozyme, Nanoparticles, Silver},
	issn = {1573-4137},
	author = {Kumar, Umesh and Ranjan, Amaresh K. and Sharan, Chandrashekhar and Hardikar, Anandwardhan A. and Pundle, Archana and Poddar, Pankaj}
}
@article {46083,
	title = {Advances in the experimental and theoretical understandings of antibiotic conjugated gold nanoparticles for antibacterial applications},
	journal = {ChemistrySelect},
	volume = {4},
	year = {2019},
	month = {JUN },
	pages = {6719-6738},
	type = {Review},
	abstract = {<p>The worldwide bacterial resistance to a wide range of antibiotics originates a global health concern and calls for the development of new antibacterial agents. Over the recent years, nanomaterials-based agents have been proven to be useful for the effective antibacterial applications. Notably, the gold nanoparticles (AuNPs) draw particular attention due to their biological inertness and easy surface functionalization. It is now established that the antibiotic functionalization on the AuNPs surfaces increases the antibacterial efficacy even towards the antibiotic-resistant bacterial cells. Moreover, the antibacterial efficacy can be further enhanced by photothermal therapy using antibiotic conjugated AuNPs. In this review article, we have reviewed the advances in the development of the synthesis methods of antibiotic conjugated AuNPs and gold nanoclusters, and their antibacterial efficacy. We have also discussed the developments in the theoretical understandings behind the interaction of antibiotic molecules with gold surface and its relation to the antibacterial activity. We believe that few parameters including the selection of antibiotic molecules, the method of its attachment to AuNPs, the purification of antibiotic conjugated AuNPs, and the quantification of conjugated antibiotic are crucial and needs to be properly addressed. Moreover, there are many other future directions discussed, for using antibiotic conjugated AuNPs more effectively for antibacterial therapy.</p>
},
	keywords = {Antibacterial, antibiotic, DFT calculations, gold nanocluster, Gold nanoparticle, multi-drug resistance, photo-thermal therapy},
	issn = {2365-6549},
	doi = {10.1002/slct.201900083},
	author = {Khandelwal, Puneet and Singh, Dheeraj K. and Poddar, Pankaj}
}
