@inbook {42771, title = {Bioconjugation of soft nanomaterials}, booktitle = {Biomedical Nanostructures}, year = {2007}, pages = {61-91}, publisher = {John Wiley \& Sons, Inc.}, organization = {John Wiley \& Sons, Inc.}, address = {Hoboken, NJ, USA.}, doi = {10.1002/9780470185834.ch4}, author = {Singh, Neetu and Blackburn, William H. and Lyon, L. Andrew} } @article {42767, title = {Bioresponsive mesoporous silica nanoparticles for triggered drug release}, journal = {Journal of the Americal Chemical Society}, volume = {133}, year = {2011}, month = {DEC}, pages = {19582-19585}, doi = {10.1021/ja206998x}, author = {Singh, Neetu and Karambelkar, Amrita and Gu, Luo and Lin, Kevin and Miller, Jordan S. and Chen, Christopher S. and Sailor, Michael J. and Bhatia, Sangeeta N.} } @article {50014, title = {Bioinspired synthesis of bridged isochromane fused pyrazoles by a silver catalyzed cascade reaction and its application for antibacterial activity}, journal = {JACS Au}, volume = {5}, year = {2025}, month = {AUG}, pages = {4184{\textendash}4195}, type = {Article}, abstract = {

A stereoselective silver catalyzed one pot vinylogous aldol addition followed by a cascade [4+2] cycloaddition reaction of α-arylidene pyrazolinones to\ in situ\ generated isochromenylium ions has been developed, which provides an unprecedented bridged [2.2.2] [3.3.1] pentacyclic [5-6-6-6-6] skeleton consisting of an isochroman, chroman, and a pyrazole unit in one molecule with good to high yields as a single diastereomer. This method offers mild reaction conditions, wide substrate compatibility, excellent scalability and easy derivatization. A DFT study was carried out to clarify the reaction mechanism. It was exciting to observe that the unprecedented bridged isochromans synthesized here have shown excellent selectivity toward Gram-positive and Gram-negative bacteria. We demonstrate that while some structures are broad spectrum antibacterial there are two distinct structures that can be explored for selective activity.

}, keywords = {Antibacterial, Bridged [2.2.2] [3.3.1], ROS, Stereoselective, Vinylogous aldol addition, [4+2] cycloaddition}, doi = {https://doi.org/10.1021/jacsau.5c00105}, author = {Singh, Bhuvnesh and Tewari, Shreya and Kaur, Manleen and Sharma, Himanshu and Vanka, Kumar and Singh, Neetu and Singh, Ravi P.} }