@article { ISI:000331675300001,
	title = {Hybrid diphosphorus ligands in rhodium catalysed asymmetric hydroformylation},
	journal = {Coordination Chemistry Reviews},
	volume = {262},
	year = {2014},
	month = {MAR},
	pages = {1-15},
	publisher = {ELSEVIER SCIENCE SA},
	address = {PO BOX 564, 1001 LAUSANNE, SWITZERLAND},
	abstract = {<p>This review aims to illustrate recent advances in the application of hybrid diphosphorus ligands for the Rh catalysed hydroformylation of alkenes, discussing the most prevalent classes of hybrid systems, i.e. phosphine-phosphinite, phosphine-phosphonite, phosphine-phosphite, phosphite-phosphoramidite and phosphite-phosphoramidite and comparing their performance with relevant C-2 symmetric counterparts. In order to introduce the field and put the results in context, a short overview on Rh hydroformylation is provided. Available spectroscopic (in situ) data on the coordination modes of hybrid phosphorus ligands and the catalytic performance of these systems in asymmetric hydroformylation of vinyl arenes are reported. Potential avenues for future research are shortly discussed. (C) 2013 Elsevier B.V. All rights reserved.</p>},
	keywords = {Asymmetric hydroformylation, Catalyst resting state, Hybrid ligand design, In situ spectroscopy, Rhodium},
	issn = {0010-8545},
	doi = {10.1016/j.ccr.2013.10.024},
	author = {Chikkali, Samir H. and van der Vlugt, Jarl Ivar and Reek, Joost N. H.}
}
@article {49777,
	title = {Rh-Catalyzed Asymmetric Hydroformylation: The Case of Substituted and Heterocyclic Olefins},
	journal = {ChemCatChem},
	volume = {17},
	year = {2025},
	month = {NOV },
	type = {Review},
	abstract = {<p>
	Asymmetric hydroformylation (AHF) of prochiral alkenes is an efficient way to synthesize optically active aldehydes, which are versatile chiral building blocks for pharmaceuticals, agrochemicals, and other fine chemicals. The purpose of this review is to take stock of developments in the last decade and shed light on the understanding of the field of AHF. So far, most of the literature methods focused on the use of Rh-based catalysts, due to high catalytic activity and excellent chemoselectivity for the aldehydes. Several chiral phosphorus ligands have been successfully developed for Rh-catalyzed AHF reactions. This review examines the role of the substrate/olefins in AHF. Several different types of {\textquoteleft}{\textquoteleft}mono-substituted{\textquoteright}{\textquoteright} terminal olefins (functionalized/nonfunctionalized) with a variety of chiral ligands have been investigated, which show high activity and excellent ee of up to 99\%. The AHF of {\textquoteleft}{\textquoteleft}di-substituted{\textquoteright}{\textquoteright} and {\textquoteleft}{\textquoteleft}tri-substituted{\textquoteright}{\textquoteright} olefins is rarely reported. This review summarizes the evolution of chiral ligands for AHF. It discusses the progress made in desymmetrizing hydroformylation. In addition, it highlights important developments in AHF carried out with and without syngas. These advances span a wide variety of alkenes. Additionally, the review offers future approaches in the field of AHF for the synthesis of optically active aldehydes.</p>
},
	keywords = {Asymmetric hydroformylation, Asymmetric transfer hydroformylation, Chiral ligands, Desymmetrizing hydroformylation, Substituted alkenes},
	issn = {1867-3880},
	doi = {10.1002/cctc.202500979},
	author = {Tewari, Tanuja and Khopade, Kishor V. and Chikkali, Samir H.}
}
