@article { ISI:000313513400013, title = {N-Heterocyclic carbene catalyzed esterification of aromatic aldehydes with alcohols under aerobic conditions}, journal = {RSC Advances}, volume = {3}, number = {6}, year = {2013}, month = {DEC}, pages = {1695-1698}, publisher = {ROYAL SOC CHEMISTRY}, address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND}, abstract = {

A simple, organocatalytic procedure for the direct oxidative esterification of a variety of aromatic aldehydes with alcohols has been described that affords the corresponding aromatic esters in high yields. The method employs N-heterocyclic carbenes as catalysts and molecular O-2 as an oxidant under ambient conditions.

}, issn = {2046-2069}, doi = {10.1039/c2ra22718e}, author = {Kiran, I. N. Chaithanya and Lalwani, Komal G. and Sudalai, Arumugam} } @article { ISI:000364968800017, title = {First enantioselective synthesis of surinamensinol B and a non-natural polysphorin analogue by a two-stereocentered hydrolytic kinetic resolution}, journal = {European Journal of Organic Chemistry}, volume = {33}, number = {33}, year = {2015}, month = {NOV}, pages = {7344-7351}, publisher = {WILEY-V C H VERLAG GMBH}, address = {POSTFACH 101161, 69451 WEINHEIM, GERMANY}, abstract = {

An efficient and economical approach to the synthesis of antitumor and anti-inflammatory surinamensinol B (1) and antimalarial polysphorin analogue 2 has been achieved with high enantiomeric purity (96\% ee) by starting from commercially available 3,4,5-trimethoxybenzaldehyde. The key steps of the strategy include a Co-catalyzed two-stereocentered hydrolytic kinetic resolution (HKR) of racemic 2[( methoxymethoxy)(3,4,5-trimethoxyphenyl)methyl] oxirane (13) as the chiral inducing step followed by a Mitsunobu reaction. Chiral epoxide 14 and chiral diol 15 were utilized in the syntheses of both compounds.

}, keywords = {Biological activity, Enantioselectivity, Kinetic resolution, Natural products, Total synthesis}, issn = {1434-193X}, doi = {10.1002/ejoc.201501009}, author = {Lalwani, Komal G. and Sudalai, Arumugam} } @article { ISI:000359136500087, title = {Organocatalytic [4+1]-annulation approach for the synthesis of densely functionalized pyrazolidine carboxylates}, journal = {RSC Advances}, volume = {5}, number = {80}, year = {2015}, month = {JUL}, pages = {65554-65559}, publisher = {ROYAL SOC CHEMISTRY}, address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND}, abstract = {

A novel one-pot [4+1]-annulation process for the asymmetric synthesis of densely functionalized pyrazolidine carboxylates is described. The in situ generated gamma-hydrazino-alpha,beta-unsaturated ester obtained via proline catalysis acts as a four-atom component, and Corey{\textquoteright}s sulfur ylide or ethyl bromoacetate acts as a one-atom carbon source to construct pyrazolidine carboxylate units in a highly enantio- and diastereoselective fashion.

}, issn = {2046-2069}, doi = {10.1039/c5ra09583b}, author = {Lalwani, Komal G. and Aher, Ravindra D. and Sudalai, Arumugam} } @article { ISI:000364436300046, title = {Short enantioselective synthesis of ephedrine, amphetamine and their analogues via two stereocentered Co(III)-catalyzed hydrolytic kinetic resolution of racemic syn-benzyloxy epoxide}, journal = {Tetrahedron Letters}, volume = {56}, number = {46}, year = {2015}, month = {NOV}, pages = {6488-6490}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

An efficient route for the synthesis of 6 drugs belonging to phenethylamine and amphetamine classes in excellent overall yields and high optical purity has been described. The strategy involves introduction of stereogenic centers by means of two-stereocentered Co(III)-catalyzed hydrolytic kinetic resolution (HKR) of racemic syn-benzyloxy epoxide followed by Pd-catalyzed regioselective cationic hydrogenation of amino alcohols as the key reactions. (C) 2015 Elsevier Ltd. All rights reserved.

}, keywords = {Amphetamine, Cationic hydrogenation, Hydrolytic kinetic resolution, Phenethylamine, Stereogenic centers}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2015.10.010}, author = {Lalwani, Komal G. and Sudalai, Arumugam} } @article { ISI:000376689000006, title = {Concise enantioselective synthesis of (+)-L-733,060 and (+)-T-2328 via sequential proline catalysis}, journal = {Synlett}, volume = {27}, number = {9}, year = {2016}, month = {JUN}, pages = {1339-1343}, publisher = {GEORG THIEME VERLAG KG}, address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY}, abstract = {

A new, sequential proline-catalyzed approach to the synthesis of (+)-L-733,060 and (+)-T-2328 in high optical purity (93\% ee) is described starting from phenyl N-Boc imine. The strategy involves proline-catalyzed Mannich reaction of an arylimine with acetaldehyde followed by -aminoxylation/Wittig olefination in a sequential fashion as the key steps.

}, keywords = {Aminoxylation, imine, Mannich reaction, olefination, sequential}, issn = {0936-5214}, doi = {10.1055/s-0035-1561346}, author = {Lalwani, Komal G. and Sudalai, Arumugam} } @article { ISI:000376695700026, title = {Organocatalytic route to enantioselective synthesis of ceramide trafficking inhibitor HPA-12}, journal = {Tetrahedron Letters}, volume = {57}, number = {22}, year = {2016}, month = {JUN}, pages = {2445-2447}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A new organocatalytic approach to the synthesis of ceramide trafficking inhibitor HPA-12 has been described starting from phenacyl bromide. The strategy involves chiral CBS reduction of gamma-ketoester and proline-catalyzed alpha-amination reaction of aldehyde followed by reduction as the key chirality inducing steps. (C) 2016 Elsevier Ltd. All rights reserved.

}, keywords = {alpha-Amination, CBS reduction, Ceramide, Organocatalytic, Proline}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2016.04.087}, author = {Lalwani, Komal G. and Sudalai, Arumugam} }