@article { ISI:000242873400029, title = {Ring closing metathesis approach to the indole alkaloid mitralactonine}, journal = {Tetrahedron Letters}, volume = {47}, number = {52}, year = {2006}, month = {DEC}, pages = {9301-9303}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, type = {Article}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

An efficient utilisation of RCM leading to a convenient synthesis of a pentacyclic indole alkaloid is described. (c) 2006 Elsevier Ltd. All rights reserved.

}, keywords = {corynanthe type alkaloid, Dihydroxylation, mitralactonine, RCM, Swern oxidation}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2006.10.106}, author = {Chavan, Subhash P. and Sharma, Pallavi and Sivappa, R. and Kalkote, Uttam R.} } @article { ISI:000244257400014, title = {Practical and facile approach towards indole alkaloids: (-)-mitralactonine}, journal = {Synlett}, number = {1}, year = {2007}, month = {JAN}, pages = {79-82}, publisher = {GEORG THIEME VERLAG KG}, type = {Article}, address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY}, abstract = {

An efficient approach to (-)-mitralactonine using Pictet-Spengler cyclisation with a highly functionalised masked aldehyde is described. Sharpless asymmetric dihydroxylation (SAD) is utilised to introduce chirality in the key substrate.

}, keywords = {alkaloids, asymmetric, cyclisations, dihydroxylations, thioacetats}, issn = {0936-5214}, doi = {10.1055/s-2006-958434}, author = {Chavan, Subhash P. and Sharma, Pallavi and Sivappa, Rasapalli and Kalkote, Uttam R.} } @article {49898, title = {Formal Synthesis of Corynanthe Indole Alkaloid ({\textpm})-Mitralactonine: Construction of α-Hydroxy-Keto Functionalized Tetracyclic Skeleton}, journal = {Chemistryselect}, volume = {10}, year = {2025}, month = {DEC }, pages = {e04415}, type = {Article}, abstract = {

An efficient synthesis of a tetracyclic skeleton common to many corynanthe alkaloids was accomplished in 10 linear steps starting from a known tetrahydro beta-carboline intermediate. The tetracyclic alpha-hydroxy keto functionalized advanced precursor of (+/-)-mitralactonine was realized using Wittig olefination, ketohydroxylation of a trisubstituted alkene, and a tandem amine unmasking-intramolecular nucleophilic displacement reaction for C-N bond formation of C/D-rings.

}, keywords = {alpha-hydroxy keto, beta-carboline, corynanthe alkaloid, intramolecular N-alkylation, mitragynine}, issn = {2365-6549}, doi = {10.1002/slct.202504415}, author = {Dumare, Nilesh B. and Sharma, Pallavi and Sivappa, Rasapalli and Chavan, Subhash P.} }