@article { ISI:000232981200014,
	title = {Aziridine carboxylate from D-glucose: synthesis of polyhydroxylated piperidine, pyrrolidine alkaloids and study of their glycosidase inhibition},
	journal = {Organic \& Biomolecular Chemistry},
	volume = {3},
	number = {20},
	year = {2005},
	month = {OCT},
	pages = {3720-3726},
	publisher = {ROYAL SOC CHEMISTRY},
	type = {Article},
	address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND},
	abstract = {<p>The D-glucose derived aziridine carboxylate 5 was obtained from (E)-ethyl-6-bromo-1,2-O-isopropylidene-3-O-benzyl-5-deoxy-alpha-D-xylo-5 -eno-heptofuranuronate 4 through conjugate addition of benzylamine and in situ intramolecular nucleophilic expulsion of bromine. The regioselective aziridine ring-opening, using water as a nucleophile, resulted in the alpha-hydroxy-beta-aminoester 6, which was exploited in the synthesis of six and five membered azasugars 1b/1c and 2b/2c, respectively The glycosidase inhibitory activity of the title compounds was evaluated.</p>},
	issn = {1477-0520},
	doi = {10.1039/b509216g},
	author = {Dhavale, Dilip D. and Kumar, K. S. A. and Chaudhari, Vinod D. and Sharma, T. and Sabharwal, Sushma G. and PrakashaReddy, J.}
}
@article { ISI:000250367600011,
	title = {Synthesis and glycosidase inhibitory studies of pentahydroxyindolizidines: D-Glucose-Derived aziridine-2-carboxylate approach},
	journal = {European Journal of Organic Chemistry},
	number = {29},
	year = {2007},
	month = {OCT},
	pages = {4895-4901},
	publisher = {WILEY-V C H VERLAG GMBH},
	type = {Article},
	address = {PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY},
	abstract = {<p>D-Glucose -derived aziridine-2-carboxylate I was converted into a-amino aldehyde 7, which, after Wittig olefination, asymmetric dihydroxylation, hydrogenation followed by LiAlH4 reduction, and N-Cbz protection, afforded two diastereomeric pyrrolidines 11a and 11b with sugar appendages. Removal of the 1,2-acetonide functionality in 11a/11b and reductive animation gave the pentahydroxyindolizidine alkaloids 6g and 6h, respectively, with (S) absolute configurations at the ring junctions. The glycosidase inhibitory activities of these compounds were studied.</p>},
	keywords = {asymmetric dihydroxylation (AD), Iminosugars, indolizidine, N-methylmorpholine, N-oxide (NNIO)},
	issn = {1434-193X},
	doi = {10.1002/ejoc.200700461},
	author = {Kumar, K. S. Ajish and Chaudhari, Vinod D. and Puranik, Vedavati G. and Dhavale, Dilip D.}
}
