@article { ISI:000332784900001,
	title = {Continuous flow nitration in miniaturized devices},
	journal = {Beilstein Journal of Organic Chemistry},
	volume = {10},
	year = {2014},
	month = {FEB},
	pages = {405-424},
	publisher = {BEILSTEIN-INSTITUT},
	type = {Review},
	address = {TRAKEHNER STRASSE 7-9, FRANKFURT AM MAIN, 60487, GERMANY},
	abstract = {<p>This review highlights the state of the art in the field of continuous flow nitration with miniaturized devices. Although nitration has been one of the oldest and most important unit reactions, the advent of miniaturized devices has paved the way for new opportunities to reconsider the conventional approach for exothermic and selectivity sensitive nitration reactions. Four different approaches to flow nitration with microreactors are presented herein and discussed in view of their advantages, limitations and applicability of the information towards scale-up. Selected recent patents that disclose scale-up methodologies for continuous flow nitration are also briefly reviewed.</p>},
	keywords = {continuous flow, flow chemistry, microreactors, nitration, nitric acid, Tubular reactor},
	issn = {1860-5397},
	doi = {10.3762/bjoc.10.38},
	author = {Kulkarni, Amol A.}
}
@article { ISI:000337539000009,
	title = {Evaluation of multipoint dosing strategy in a miniaturized tubular reactor: nitration of salicylic acid},
	journal = {Chemical Engineering \& Technology},
	volume = {37},
	number = {6},
	year = {2014},
	month = {JUN},
	pages = {927-937},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY},
	abstract = {<p>A 2D non-isothermal reaction engineering model for a tubular reactor was developed for a complex reaction network of salicylic acid nitration. The influence of different operating and design parameters was studied to minimize the amount of secondary nitration products and limit the maximum temperature inside the reactor. Critical temperature effects were observed for larger reaction tubes, whereas close to isothermal conditions were perceived in smaller tubes. With single-point dosing of both reactants, complete conversion can be achieved but formation of secondary nitration products cannot be avoided. For a given number of dosing points, a suitable combination of the operating parameters allowed to achieve complete conversion and better yield of the desired product.</p>},
	keywords = {Multipoint injection, nitration, Plug-flow reactor, Salicylic acid, Tubular reactor},
	issn = {0930-7516},
	doi = {10.1002/ceat.201300427},
	author = {Debnath, Soujoy and Kienle, Achim and Kulkarni, Amol A.}
}
