@article { ISI:000252094200024, title = {Efficient synthesis of 2,4-disubstituted thiazoles using ionic liquid under ambient conditions: a practical approach towards the synthesis of Fanetizole}, journal = {Tetrahedron }, volume = {63}, number = {45}, year = {2007}, month = {NOV}, pages = {11066-11069}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, type = {Article}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A highly efficient and rapid synthesis of 2-amino-4-arylthiazoles and 2-methyl-4-arylthiazole from alpha-bromoketone and thiourea/thioamide is described using room temperature ionic liquid at ambient conditions. The method is simple, rapid and practical, generating thiazole derivatives in excellent isolated yields. This protocol is utilized for a commercially feasible synthesis of an anti-inflammatory agent, Fanetizole. (c) 2007 Published by Elsevier Ltd.

}, keywords = {alpha-bromo ketone, ionic liquids, thiazoles, thiourea/thioamide}, issn = {0040-4020}, doi = {10.1016/j.tet.2007.08.036}, author = {Potewar, Taterao M. and Ingale, Sachin A. and Srinivasan, Kumar V.} } @article { ISI:000256179700013, title = {Catalyst-free efficient synthesis of 2-aminothiazoles in water at ambient temperature}, journal = {Tetrahedron}, volume = {64}, number = {22}, year = {2008}, month = {MAY}, pages = {5019-5022}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, type = {Article}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A highly efficient and facile method has been described for the synthesis of substituted 2-aminothiazoles in water without any added catalyst or co-organic solvent. The reaction was carried out at ambient temperature and the products were obtained in excellent isolated yields. The developed protocol is successfully applied for the preparation of an anti-inflammatory drug, fanetizole. (C) 2008 Elsevier Ltd. All rights reserved.

}, keywords = {2-aminothiazoles, ambient temperature, environment-friendly synthesis, Water}, issn = {0040-4020}, doi = {10.1016/j.tet.2008.03.082}, author = {Potewar, Taterao M. and Ingale, Sachin A. and Srinivasan, Kumar V.} } @article { ISI:000260411100014, title = {Efficient and eco-friendly synthesis of 2-amino-1,3-selenazoles in an ionic liquid/water system under ambient conditions}, journal = {Arkivoc}, number = {12}, year = {2008}, month = {JAN}, pages = {117-125}, publisher = {ARKAT USA INC}, type = {Article}, address = {C/O ALAN R KATRITZKY, UNIV FLORIDA, DEPT CHEMISTRY, PO BOX 117200, GAINESVILLE, FL 32611 USA}, abstract = {

An efficient and eco-friendly synthesis of 2-amino-1,3-selenazoles in ionic liquid/water solvent system is described. The paper describes synthesis of 2-amino-1,3-selenazoles by condensation of various phenacyl bromide with selenourea under ambient conditions in short reaction times. This protocol has notable advantages such as the absence of any added catalyst, simple operation and excellent yields of products and recyclability of the ionic liquid.

}, keywords = {2-Amino-1, 3-selenazoles, ambient conditions, heterocycles, ionic liquid/water system, selenoureas, substituted phenacyl bromide}, issn = {1551-7004}, author = {Potewar, Taterao M. and Ingale, Sachin A. and Srinivasan, Kumar V.} } @article { ISI:000260209800002, title = {Efficient synthesis of quinoxalines in the ionic liquid 1-n-butylimidazolium tetrafluoroborate ([Hbim]BF4) at ambient temperature}, journal = {Synthetic Communications}, volume = {38}, number = {21}, year = {2008}, month = {FEB}, pages = {3601-3612}, publisher = {TAYLOR \& FRANCIS INC}, type = {Article}, address = {325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA}, abstract = {

Quinoxaline derivatives have been synthesized in excellent yields using an ionic liquid (IL) (viz., 1-n-butylimidazolium tetrafluoroborate) as a reaction medium as well as promoter from various 1,2-diketones and aryl-1,2-diamines. The process is general for the synthesis of quinoxaline derivatives from aromatic as well as aliphatic-1,2-diketones. The advantages of the present method are ambient reaction temperature, simplicity of operation, high yields of products, the recyclability of the IL, and ecofriendly nature of the reaction medium.

}, keywords = {1, 2-diamines, 2-Diketones, Aryl-1, ionicliquid(IL), quinoxalines}, issn = {0039-7911}, doi = {10.1080/00397910802054271}, author = {Potewar, Taterao M. and Ingale, Sachin A. and Srinivasan, Kumar V.} } @article { ISI:000262196200011, title = {Synthesis of tryptanthrin and deoxyvasicinone by a regioselective lithiation-intramolecular electrophilic reaction approach}, journal = {Arkivoc}, year = {2008}, month = {JAN}, pages = {100-U9}, publisher = {ARKAT USA INC}, type = {Article}, address = {C/O ALAN R KATRITZKY, UNIV FLORIDA, DEPT CHEMISTRY, PO BOX 117200, GAINESVILLE, FL 32611 USA}, abstract = {

An efficient synthesis of the 4(3H)-quinazolinone-based alkaloids, tryptanthrin and deoxyvasicinone has been achieved in good overall yields by using the strategy of regioselective lithiation-intramolecular electrophilic reaction as a key-step. Both the molecules have been synthesized in just two-steps from readily available starting materials.

}, keywords = {4(3H)-Quinazolinone heterocycles, deoxyvasicinone, lithiation-intramolecular electrophilic reaction, tryptanthrin}, issn = {1424-6376}, author = {Potewar, Taterao M. and Ingale, Sachin A. and Srinivasan, Kumar V.} }