@article { ISI:000257640400029,
	title = {Serine protease inhibitor from hemolymph of green mussel, perna viridis},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	volume = {18},
	number = {14},
	year = {2008},
	month = {JUL},
	pages = {3963-3967},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>Bioactivity guided fractions of cell-free hemolymph of bacterially challenged marine mussel, Perna viridis led to the isolation of a novel quaternary alkaloid 1, which was identified by its spectral data. The isolated molecule 1 has been found to be a potent serine protease inhibitor ( SPI) showing IC(50) and K(i) values of 102.5 and 97.1-104.68 mu M, respectively. The E(t)/K(i) value of SPI is 6.3, whereas E(t)/K(m) value is 1.04. The Van{\textquoteright}t Hoff analysis showed that the value of K(i) decreases with increase in temperature, and the binding of the inhibitor is entropically driven. (c) 2008 Elsevier Ltd. All rights reserved.</p>},
	keywords = {hemolymph, Natural product, Perna viridis, protease inhibitor},
	issn = {0960-894X},
	doi = {10.1016/j.bmcl.2008.06.010},
	author = {Khan, M. S. and Goswami, U. and Rojatkar, S. R. and Khan, Mohammad Islam}
}
