@article { ISI:000259450800027,
	title = {Continuous flow nitration of salicylic acid},
	journal = {Organic Process Research \& Development},
	volume = {12},
	number = {5},
	year = {2008},
	month = {SEP},
	pages = {995-1000},
	publisher = {AMER CHEMICAL SOC},
	type = {Article},
	address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA},
	abstract = {<p>Continuous flow nitration of salicylic acid using HNO3/AcOH was studied in the SS316 tubular microreactor. At specific reaction conditions, complete conversion of the reactant was achieved in less than 7 min. It yielded only mononitro derivatives with a higher selectivity of 5-nitrosalicylic acid. Presence of the lower amount of acetic acid in the reaction mixture was seen to be detrimental, leading to precipitation of the desired product (5-nitrosalicylic acid). Reaction at higher temperatures yielded byproducts. The continuous mode operation using the system comprising the microdevices was demonstrated for 2 h with consistent composition at the outlet.</p>},
	issn = {1083-6160},
	doi = {10.1021/op800112u},
	author = {Kulkarni, Amol A. and Nivangune, Nayana T. and Kalyani, Vishwanath S. and Joshi, Ramesh A. and Joshi, Rohini R.}
}
