@article { ISI:000364803200006,
	title = {Silicon incorporated morpholine antifungals: design, synthesis, and biological evaluation},
	journal = {ACS Medicinal Chemistry Letters},
	volume = {6},
	number = {11},
	year = {2015},
	month = {NOV},
	pages = {1111-1116},
	publisher = {AMER CHEMICAL SOC},
	address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA},
	abstract = {<p>Known morpholine class antifungals (fenpropimorph, fenpropidin, and amorolfine) were synthetically modified through silicon incorporation to have 15 sila-analogues. Twelve sila-analogues exhibited potent antifungal activity against different human fungal pathogens such as Candida albicans, Candida glabrata, Candida tropicalis, Cryptococcus neoformans, and Aspergillus niger. Si la-analogue 24 (fenpropimorph analogue) was the best in our hands, which showed superior fungicidal potential than fenpropidin, fenpropimorph, and amorolfine. The mode of action of sila-analogues was similar to morpholines, i.e., inhibition of sterol reductase and sterol isomerase enzymes of ergosterol synthesis pathway.</p>},
	keywords = {Antifungal drugs, Candida albicans, ergosterol biosynthesis, morpholines, sila-analogues},
	issn = {1948-5875},
	doi = {10.1021/acsmedchemlett.5b00245},
	author = {Jachak, Gorakhnath R. and Ramesh, Remya and Sant, Duhita G. and Jorwekar, Shweta U. and Jadhav, Manjusha R. and Tupe, Santosh G. and Deshpande, Mukund V. and Reddy, D. Srinivasa}
}
@article {47699,
	title = {Synthesis and biological evaluation of hoshionolactam-based compounds},
	journal = {European Journal of Organic Chemistry},
	volume = {2021},
	year = {2021},
	month = {APR },
	pages = {2212-2218},
	type = {Article},
	abstract = {In search of novel antitrypanosomal agents based on hoshinolactam (IC50=3.9 nM), we disclose the synthesis and biological evaluations of 14 different analogues of the natural product using combinations of different acids and lactams. Antitrypanosomal activity assays revealed that the synthesized analogues were less potent than the parent natural product.},
	keywords = {Hoshinolactam, Ozonolysis, Parasitic diseases, Trypanosoma},
	issn = {1434-193X},
	doi = {10.1002/ejoc.202001588},
	author = {Jachak, Gorakhnath R. and Elizebath, Drishya and Shukla, Anurag and Shanmugam, Dhanasekaran and Reddy, D. Srinivasa}
}
