@article { ISI:000260843200008,
	title = {Efficacy of 4-methyl-7-hydroxy coumarin derivatives against vectors aedes aegypti and culex quinquefasciatus},
	journal = {Indian Journal of Experimental Biology},
	volume = {46},
	number = {11},
	year = {2008},
	month = {NOV},
	pages = {788-792},
	publisher = {NATL INST SCIENCE COMMUNICATION},
	type = {Article},
	address = {DR K S KRISHNAN MARG, NEW DELHI 110 012, INDIA},
	abstract = {<p>4-Methyl-7-hydroxy coumarin is considered as a lead molecule as a biopesticide. Its mono bromo and tribromo derivatives were synthesized. Two more derivatives were synthesized by acylation. Compound 1 (3.6,8-tribromo-7-hydroxy-4-methyl-chromen-2-one) was found to be the most potent against IV(th) instar larvae of C. quinquefasciatus and A. aegypti the LC(50) being 1.49 and 2.23 ppm respectively. It showed 100\% larval mortality at 25 ppm against A. aegypti and at 10 ppm against C. quinquefasciatus. Compounds 1 and 2 (3,6,8-tribromo-7-hydroxy-4-methyl-chromen-2{\textquoteright}-oxo-2H-chromen-7-yl acetate) showed remarkable ovicidal activity. Significant reduction of 80-85\%, hatching of eggs of both mosquito species was observed at the highest dose of 100 ppm. The hatched larvae showed 100\% mortality in the successive instars. Compounds 3 and 4 (3-bromo-7-hydroxy-4-methyl-chromen-2-one and 3-bromo-4-methyl-2{\textquoteright}-oxo-2H-chromen-7-yl acetate) showed moderate activity against both mosquito species.</p>},
	keywords = {4-Methyl-7-hydroxy coumarin, Aedes aegypti, Culex quinquefasciatus, Larval mortality, Ovicidal activity},
	issn = {0019-5189},
	author = {Deshmukh, Madhavi and Pawar, Pushpa and Joseph, Mary P. and Phalgune, Usha and Kashalkar, Rajashree and Deshpande, Nirmala R.}
}
@article { ISI:000267784200012,
	title = {Susceptibility of aedes aegypti and culex quinquefasciatus larvae to gedunin-related limonoids},
	journal = {Chemistry \& Biodiversity},
	volume = {6},
	number = {6},
	year = {2009},
	month = {JUN},
	pages = {897-902},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY},
	abstract = {<p>The major non-azadirachtin limonoids such as gedunin (1), epoxyazadiradione (3), nimbocinol (4), and nimolicinol (5) from Azadirachta indica A. Juss ({\textquoteright}neem{\textquoteright}) and their derivatives were evaluated for their toxic action against fourth instar larvae of Aedes aegypti L. and Culex quinquefasciatus SAY. Gedunin exhibited 100\% toxic action against both the mosquito larvae at 50 and 10 ppm. Epoxyazadiradione and epoxynimolicinol also showed significant toxicities (\&gt;= 50\%) against larvae of both mosquito species at 50 ppm. These neem limonoids can have benefits in mosquito-control programs.</p>},
	issn = {1612-1872},
	author = {Gurulingappa, Hallur and Tare, Vrushali and Pawar, Pushpa and Tungikar, Vijay and Jorapur, Yogesh R. and Madhavi, Sriram and Bhat, Sujata V.}
}
