@article { ISI:000238443200008,
	title = {Production of lactic acid and fructose from media with cane sugar using mutant of Lactobacillus delbrueckii NCIM 2365},
	journal = {Letters in Applied Microbiology},
	volume = {43},
	number = {1},
	year = {2006},
	month = {JUL},
	pages = {53-57},
	publisher = {BLACKWELL PUBLISHING},
	type = {Article},
	address = {9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND},
	abstract = {<p>Aims: To examine the potential of Lactobacillus delbrueckii mutant, Uc-3 to produce lactic acid and fructose from sucrose-based media. Methods and Results: The mutant of L. delbrueckii NCIM 2365 was cultivated in shake flask containing hydrolysed cane sugar (sucrose)-based medium. The lactic acid yield and volumetric productivity with hydrolysed cane concentration up to 200 g l(-1) were in the range of 92-97\% of the theoretical value and between 2.7 and 3.8 g l(-1) h(-1), respectively. The fructose fraction of the syrup produced was more than 95\% when the total initial sugar concentration in the medium was higher (150-200 g l(-1)). There are no unwanted byproducts detected in the fermentation broth. Conclusions: We demonstrated that L. delbrueckii mutant Uc-3 was able to utilize glucose preferentially to produce lactic acid and fructose from hydrolysed cane sugar in batch fermentation process. Significance and Impact of the Study: These findings will be useful in the production of lactic acid and high fructose syrups using media with high concentrations of sucrose-based raw materials. This approach can lead to modification of the traditional fermentation processes to obtain value-added byproducts, attaining better process economics.</p>},
	keywords = {fructose accumulation, hydrolyzed cane sugar, lactic acid production, Lactobacillus delbrueckii, Mutant},
	issn = {0266-8254},
	doi = {10.1111/j.1472-765X.2006.01907.x},
	author = {Patil, S. S. and Kadam, S. R. and Patil, S. S. and Bastawade, Kulbhushan B. and Khire, Jayant Malhar and Gokhale, D. V.}
}
@article { ISI:000275455500010,
	title = {Strain improvement of lactobacillus lactis for d-lactic acid production},
	journal = {Biotechnology Letters},
	volume = {32},
	number = {4},
	year = {2010},
	month = {APR},
	pages = {517-520},
	publisher = {SPRINGER},
	address = {VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS},
	abstract = {<p>Three mutants, isolated by repeated UV mutagenesis of Lactobacillus lactis NCIM 2368, produced increased d-lactic acid concentrations. These mutants were compared with the wild type using 100 g hydrolyzed cane sugar/l in the fermentation medium. One mutant, RM2-24, produced 81 g lactic acid/l which was over three times that of the wild type. The highest d-lactic acid (110 g/l) in batch fermentation was obtained with 150 g cane sugar/l with a 73\% lactic acid yield. The mutant utilizes cellobiose efficiently, converting it into d-lactic acid suggesting the presence of cellobiase. Thus, this strain could be used to obtain d-lactic acid from cellulosic materials that are pre-hydrolyzed with cellulase.</p>},
	keywords = {Cellobiose utilization, D-Lactic acid production, Lactobacillus lactis, Mutant, Sucrose (cane sugar)},
	issn = {0141-5492},
	doi = {10.1007/s10529-009-0187-y},
	author = {Joshi, D. S. and Singhvi, M. S. and Khire, Jayant Malhar and Gokhale, D. V.}
}
