@article { ISI:000246298900004,
	title = {Practical formal synthesis of D-(+)-biotin from 4-formylazetidin-2-one},
	journal = {Synthesis-Stuttgart},
	number = {8},
	year = {2007},
	month = {APR},
	pages = {1159-1164},
	publisher = {GEORG THIEME VERLAG KG},
	type = {Article},
	address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY},
	abstract = {<p>A practical synthesis of (3S,6R)-1,3-dibenzyltetrahydro-1H-furo[3,4-d]imidazole-2,4-dione, an important intermediate in the synthesis of biotin, from 4-formyl-3-mesyloxyazetidin-2-one has been achieved. Acid-catalyzed azetidin-2-one ring opening followed by a one-pot conversion of diamine hydrochloride to a cyclic urea and hydroxymethylene to chloromethylene by triphosgene to obtain (4S,5R)-methyl-1,3-dibenzyl-5-chloromethyl-2-oxoimidazolidine-4-carboxyl ate is the key step in this synthesis.</p>},
	keywords = {azetidin-2-one, beta-Lactams, cyclization, Lactone, reduction},
	issn = {0039-7881},
	doi = {10.1055/s-2007-965992},
	author = {Kale, Ajaykumar S. and Puranik, Vedavati G. and Deshmukh, Abdul Rakeeb A. S.}
}
@article { ISI:000264538000029,
	title = {Efficient formal synthesis of (S)-dapoxetine from enantiopure 3-hydroxy azetidin-2-one},
	journal = {Tetrahedron},
	volume = {65},
	number = {12},
	year = {2009},
	month = {MAR},
	pages = {2605-2609},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>An efficient formal synthesis of S-(+) dapoxetine starting from 3-hydroxy azetidin-2-one is described. The intermediate (S)-3-(dimethyl amino)-3-phenylpropan-1-ol was synthesized in enantiopure form starting with 3-hydroxy azetidin-2-one in seven steps. (c) 2008 Elsevier Ltd. All rights reserved.</p>},
	keywords = {Azetidin 2 ones, beta-Lactams, Enantioselective synthesis, reduction, Staudinger reaction},
	issn = {0040-4020},
	doi = {10.1016/j.tet.2008.11.042},
	author = {Chincholkar, Pinak M. and Kale, Ajaykumar S. and Gumaste, Vikas K. and Deshmukh, Abdul Rakeeb A. S.}
}
