@article {42468, title = {Engaging zwitterions in carbon-carbon and carbon-nitrogen bond- forming reactions: a promising synthetic strategy}, journal = {Accounts of Chemical Research}, volume = {39}, year = {2006}, month = {JUN}, pages = {520{\textendash}530}, type = {Article}, abstract = {

An Account of carbon-carbon and carbon-nitrogen bond-forming reactions mediated by zwitterions generated by the addition of organic nucleophiles to activated unsaturated systems highlighting their synthetic potential is presented.

}, doi = {10.1021/ar0502026}, author = {Nair, Vijay and Menon, Rajeev S. and Sreekanth, A. R. and Abhilash, N. and Biju, Akkattu T.} } @article {42465, title = {Efficient higher-order cycloaddition reactions of 8,8-dicyanoheptafulvenes with dienes}, journal = {Synthesis-Stuttgart }, year = {2007}, month = {JUN}, pages = {1833-1836}, type = {Article}, abstract = {

The cycloaddition reactions of 8,8-dicyanoheptafulvene with electron-rich dienes afforded the higher order cycloaddition products in excellent yields. With cyclic dienes as well as dimeth-oxybutadiene the [8+2] adducts were obtained exclusively. With methyl- and dimethylbutadienes the [6+4] adducts were the only products isolated.

}, keywords = {cycloadditions - bicyclic compounds - polycycles - di-cyanoheptafulvene - tetrahydroazulenes}, doi = {10.1055/s-2007-983711}, author = {Nair, Vijay and Gopalakrishnan Abhilash, K. and Biju, Akkattu T. and Eringathodi, Suresh} } @article { ISI:000295921500010, title = {Employing homoenolates generated by NHC catalysis in carbon-carbon bond-forming reactions: state of the art}, journal = {Chemical Society Reviews}, volume = {40}, number = {11}, year = {2011}, month = {JUL}, pages = {5336-5346}, publisher = {ROYAL SOC CHEMISTRY}, address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND}, abstract = {

Homoenolate is a reactive intermediate that possesses an anionic or nucleophilic carbon beta to a carbonyl group or its synthetic equivalent. The recent discovery that homoenolates can be generated from alpha,beta-unsaturated aldehydes via N-Heterocyclic Carbene (NHC) catalysis has led to the development of a number of new reactions. A majority of such reactions include the use of carbon-based electrophiles, such as aldehydes, imines, enones, dienones etc. resulting in the formation of a variety of annulated as well as acyclic products. The easy availability of chiral NHCs has allowed the development of very efficient enantioselective variants of these reactions also. The tolerance showed by NHCs towards magnesium and titanium based Lewis acids has been exploited in the invention of cooperative catalytic processes. This tutorial review focuses on these and other types of homoenolate reactions reported recently, and in the process, updates the previous account published in 2008 in this journal.

}, issn = {0306-0012}, doi = {10.1039/c1cs15139h}, author = {Nair, Vijay and Menon, Rajeev S. and Biju, Akkattu T. and Sinu, C. R. and Paul, Rony Rajan and Jose, Anu and Sreekumar, Vellalath} }