@article { ISI:000265958900008,
	title = {First ionic liquid-promoted Kabbe condensation reaction for an expeditious synthesis of privileged bis-spirochromanone scaffolds},
	journal = {Tetrahedron Letters},
	volume = {50},
	number = {22},
	year = {2009},
	month = {JUN},
	pages = {2643-2648},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>A variety of privileged bis-spirochromanones were synthesized for the First time from 4,6-diacetyl resorcinol in one-pot by carrying out the Kabbe condensation in loom temperature ionic liquid [bbim]Br. (C) 2009 Elsevier Ltd. All rights reserved.</p>},
	keywords = {Bis-spirochromanone, Ionic liquid, Kabbe condensation, Morpholine},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2009.03.104},
	author = {Muthukrishnan, Murugan and Basavanag, U. M. V. and Puranik, Vedavati G.}
}
@article {43027,
	title = {Spirochromone-chalcone conjugates as antitubercular agents: synthesis, bio evaluation and molecular modeling studies},
	journal = {RSC Advances},
	volume = {5},
	year = {2015},
	month = {DEC},
	abstract = {<p>A new series of spirochromone annulated chalcone conjugates were synthesized and evaluated for their antitubercular activity against Mycobacterium tuberculosis H37Rv strain. These compounds were subjected to molecular modeling studies using docking and chemoinformatics based approaches. The docking simulations were performed against a range of known receptors for chalcone derived compounds to reveal MTB phosphotyrosine phosphatase B [MtbPtpB] protein as the most probable target based on the high binding affinity scores. Five compounds exhibit significant inhibition, showing minimum inhibitory concentration values i.e. MIC values ranging from 3.13{\textendash}12.5 μg mL-1. Further analysis of the synthesized compounds with known and in-house developed chemoinformatics tools unequivocally established their potential as anti-tubercular compounds. QSAR modeling revealed a quantitative relationship between biological activities and frontier molecular orbital energies of synthesized compounds. The predictive model can be employed further for virtual screening of new compounds in this series.</p>},
	doi = {10.1039/C5RA21737G},
	author = {Mujahid, Mohammad and Perumal, Yogeeswari and Sriram, D. and Basavanag, U. M. V. and D{\i}az-Cervantes, Erik and Cordoba-Bahena, Luis and Robles, Juvencio and Gonnade, Rajesh Ghanshyam and Karthikeyan, Muthukumarasamy and Vyas, Renu and Krishnan, M. Muthu}
}
