@article { ISI:000269760900028,
	title = {Design and synthesis of bile acid-based amino sterols as antimicrobial agents},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	volume = {19},
	number = {18},
	year = {2009},
	month = {SEP},
	pages = {5411-5414},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>New bile acid-based amino sterols were synthesized in good yields from C-3 beta-oxiranes as key intermediates. These derivatives were evaluated for their in vitro antimicrobial properties against human pathogens. These compounds showed better antibacterial activity as compared to antifungal activity. Compounds 21 and 22 showed comparable antibacterial activity to gentamicin against Staphylococcus aureus with IC(50) values of 5.14 and 4.46 mu g/mL. This is the first report for the synthesis of C-3 beta-oxiranes on the steroids having A/B cis ring junction and these oxiranes have been used for the synthesis of amino sterols 17, 18, 21, and 22. (C) 2009 Elsevier Ltd. All rights reserved.</p>},
	keywords = {Amino sterols, Antibacterial agent, bile acid, Oxirane},
	issn = {0960-894X},
	doi = {10.1016/j.bmcl.2009.07.117},
	author = {Aher, Nilkanth G. and Pore, Vandana S. and Mishra, Nripendra N. and Shukla, Praveen K. and Gonnade, Rajesh G.}
}
@article { ISI:000262707000040,
	title = {Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	volume = {19},
	number = {3},
	year = {2009},
	month = {FEB},
	pages = {759-763},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>Fluconazole based novel mimics containing 1,2,3-triazole were designed and synthesized as antifungal agents. Their antifungal activities were evaluated in vitro by measuring the minimal inhibitory concentrations (MICs). Compounds 12, 15, and 16 were found to be more potent against Candida fungal pathogens than control drugs fluconazole and amphotericin B. The studies presented here provide structural modi. cation of fluconazole to give 1,2,3-trazole containing molecules. Furthermore, these molecules were evaluated in vivo against Candida albicans intravenous challenge in Swiss mice and antiproliferative activities were tested against human hepatocellular carcinoma Hep3B and human epithelial carcinoma A431. It was found that compound 12 resulted in 97.4\% reduction in fungal load in mice and did not show any profound proliferative effect at lower dose (0.001 mg/ml). (C) 2008 Elsevier Ltd. All rights reserved.</p>},
	keywords = {1, 2, 3-Triazole, Antifungal agent, bile acid, Conjugates, Fluconazole},
	issn = {0960-894X},
	doi = {10.1016/j.bmcl.2008.12.026},
	author = {Aher, Nilkanth G. and Pore, Vandana S. and Mishra, Nripendra N. and Kumar, Awanit and Shukla, Praveen K. and Sharma, Aanchal and Bhat, Manoj K.}
}
