@article {49599,
	title = {Unlocking thermodynamic enolate for kinetically controlled desymmetrizing vinylogous (4+1) carbospiroannulation},
	journal = {Chemistry-A European Journal},
	volume = {31},
	year = {2025},
	month = {MAY},
	type = {Article},
	abstract = {<p>
	An unprecedented thermodynamically unfavorable (4+1) deysmmetrizing spiroannulation through a thermodynamic enolate intermediate, enabling a single-step synthesis of ubiquitous scaffolds such as all-carbon chiral spirocycles, is disclosed. In this spiroannulation, we present a vinylogous organocatalytic enantioselective desymmetrizing (4+1) cycloaddition approach involving alkylidene malononitrile and cyclopent-1,3-dienone. This carbospiroannulation method produces functionally enriched spiro[4,4]nonane structures with three stereocenters, has presented good-to-high yields and enantiomeric ratios. Detailed DFT calculations reveal an intriguing reaction mechanism, which validates our observations.</p>
},
	keywords = {3-diones, alkylidene malononitrile, cyclopent-1, quaternary stereocenters, spiro compounds, thermodynamic enolate},
	issn = {0947-6539},
	doi = {10.1002/chem.202500671},
	author = {Singh, Sanjay and Singh, Abhijeet and Pandya, Rinu and Vanka, Kumar and Singh, Ravi P.}
}
