@article { ISI:000296195400018, title = {Phosphine-mediated synthesis of 1,4-oxazepine- and 1,5-oxazocine-based sugar hybrids from deoxysugar azides}, journal = {Synthesis-Stuttgart}, volume = {21}, number = {21}, year = {2011}, month = {NOV}, pages = {3523-3529}, publisher = {GEORG THIEME VERLAG KG}, address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY}, abstract = {

An efficient and convenient method was developed for the synthesis of novel 1,4-oxazepine- and 1,5-oxazocine-based sugar hybrids from readily available deoxysugar azides by means of tributylphosphine-mediated tandem reactions. The resulting glycoconjugates might be useful in increasing the diversity of sugar backbones, and could find applications as potential glycomimetics and in drug discovery.

}, keywords = {Alkynes, azides, carbohydrates, heterocycles, oxazepines, oxazocines, Tandem reactions}, issn = {0039-7881}, doi = {10.1055/s-0030-1260218}, author = {Kurhade, Suresh E. and Salunkhe, Videsh T. and Siddaiah, V. and Bhuniya, Debnath and Reddy, D. Srinivasa} } @article {48068, title = {Postmodification of voxelotor (GBT 440) via [Rh]-catalyzed cross dehydrogenative coupling with olefins br}, journal = {Bioorganic \& Medicinal Chemistry Letters}, volume = {77}, year = {2022}, month = {DEC}, pages = {129022}, type = {Article}, abstract = {

The directed Rh(III)-catalyzed cross dehydrogenative coupling of the pyrazole unit of the GBT-440 scaffold has been explored with simple as well as conjugated olefins to synthesize post-functionalized GBT-440 analogues. The screening of these synthesized compounds for improving the oxygen binding efficiency of the hemoglobin isolated from the sickled red blood cells revealed that some of these compounds are as good as GBT-440.

}, keywords = {CDC Coupling, GBT-440 (Voxelotor), Rh(III) catalysis, sickle cell anemia}, issn = {0960-894X}, doi = {10.1016/j.bmcl.2022.129022}, author = {Kalshetti, Rupali G. and Rajput, Raveena and Motiwala, Zenia and Reddy, D. Srinivasa and Kulkarni, Kiran A. and V. Ramana, Chepuri} } @article {49731, title = {Peganutonin A: computationally informed synthesis of its revised structure}, journal = {Journal of Natural Products}, volume = {88}, year = {2025}, month = {APR}, pages = {1253-1258}, type = {Article}, abstract = {

The structure of the recently isolated natural product peganutonin A was shown to be incorrect by analysis of the reported spectroscopic data, and therefore, the structure was reassigned utilizing computational methods. Subsequently, the computationally proposed reassignment was confirmed by total synthesis, which was achieved in seven steps from 6-methoxyindole. It is assumed that peganutonin A is not a natural product but an artifact arising from photooxidation of the alkaloid harmaline.

}, issn = {0163-3864}, doi = {10.1021/acs.jnatprod.5c00322}, author = {Saranya, N. Sathya Sai and Choudhury, Rahul and Supekar, Prathmesh R. and Beduru, Srinivas and Williams, Craig M. and Elyashberg, Mikhail E. and Kutateladze, Andrei G. and Bates, Roderick W. and Reddy, D. Srinivasa} }