@article {42901,
	title = {Identification of noreremophilane-based inhibitors of angiogenesis using zebrafish assays},
	journal = {Organic \& Biomolecular Chemistry},
	volume = {14},
	year = {2016},
	month = {OCT},
	pages = {1569-1578},
	author = {Muthukumarasamy, Kalai Mangai and Handore, Kishor L. and Kakade, Dipti N. and Shinde, Madhuri V. and Ranjan, Shashi and Kumar, Naveen and Sehrawat, Seema and Sachidanandan, Chetana and Reddy, D. Srinivasa}
}
@article {43744,
	title = {Identification and synthesis of mycalol analogues with improved potency against anaplastic thyroid carcinonia cell lines},
	journal = {Journal of Natural Products},
	volume = {80},
	year = {2017},
	month = {APR},
	pages = {1125-1133},
	type = {Article},
	abstract = {The marine metabolite mycalol (1) has a specific inhibitory activity on cells of anaplastic thyroid carcinoma (ATC), a very aggressive and rare cancer that does not have effective conventional therapy. In this study, we describe six new related analogues (2-7) that differ in the length of the terminal alkyl residue and the presence of acetate or 3S-hydroxybutyrate (3S)-3HB as a substituent at C-19. Despite the structural{\textquoteright} analogies, some of the new members were significantly more-cytotokic than 1 on cell lines,derivecl from human ATC. Structures inclusive of the 2{\textquoteright}R,3R,4S,7R,8S,19R absolute configuration were asigned to 2-7 on the basis of detailed spectroscopic analysis, synthesis of different isomers, and application of ECD and Mosher{\textquoteright}s methods. This work led to the identification of mycal61-578 (3) as the most potent analogue, with an IC50 of 2.3 mu M on FRO cells:},
	doi = {10.1021/acs.jnatprod.7b00043},
	author = {Cutignano, Adele and Seetharamsingh, B. and D{\textquoteright}Angelo, Daniela and Nuzzo, Genoveffa and Khairnar, Pankaj V. and Fusco, Alfredo and Reddy, D. Srinivasa and Fontana, Angelo}
}
@article {43826,
	title = {Identification of new anti-inflammatory agents based on nitrosporeusine natural products of marine origin},
	journal = {European Journal of Medicinal Chemistry},
	volume = {135},
	year = {2017},
	month = {JUL},
	pages = {89-109},
	type = {Article},
	abstract = {Nitrosporeusines A and B are two recently isolated marine natural products with novel skeleton and exceptional biological profile. Interesting antiviral activity of nitrosporeusines and promising potential in curing various diseases, evident from positive data from various animal models, led us to investigate their anti-inflammatory potential. Accordingly, we planned and synthesized nitrosporeusines A and B in racemic as well as enantiopure forms. The natural product synthesis was followed by preparation of several analogues, and all the synthesized compounds were evaluated for in vitro and in vivo anti-inflammatory potential. Among them, compounds 25, 29 and 40 significantly reduced levels of nitric oxide (NO), reactive oxygen species (ROS) and pro-inflammatory cytokines. In addition, these compounds suppressed several pro-inflammatory mediators including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nuclear factor-kappa B (NF -kappa B), and thereby can be emerged as potent anti-inflammatory compounds. Furthermore, all possible isomers of lead compound 25 were synthesized, characterized and profiled in same set of assays and found that one of the enantiomer (-)-25a was superior among them. (C) 2017 Elsevier Masson SAS. All rights reserved.},
	doi = {10.1016/j.ejmech.2017.04.015},
	author = {Philkhana, Satish Chandra and Verma, Abhishek Kumar and Jachak, Gorakhnath R. and Hazra, Bibhabasu and Basu, Anirban and Reddy, D. Srinivasa}
}
@article {47806,
	title = {Identification of a novel series of potent organosilicon mosquito repellents},
	journal = {ACS Omega},
	volume = {6},
	year = {2021},
	month = {NOV},
	pages = {31236-31243},
	type = {Article},
	abstract = {Mosquito control by personal protection is one of the most efficient ways of curtailing deadly diseases such as malaria and dengue with the potential to save millions of lives per year. DEET (N,N-diethyl-3-methyl benzamide) is currently considered as the gold standard for mosquito repellents, being used for the past several decades. Control by DEET, however, is being threatened by emerging resistance among mosquitoes. To address this concern and also to improve protection times, we synthesized a novel series of 25 silicon-containing acyl piperidines using acid{\textendash}amine coupling protocol and tested their activity against Aedes aegypti in mosquito-repellent assays. Several compounds from this series appear to possess good mosquito-repellent properties. Most notably, at 0.5 mg/cm2 concentrations, the mean protection time for NDS100100 was 756 min, which was higher than that of DEET (616 min). The details of design, synthesis, and biological evaluation are discussed herein.},
	doi = {10.1021/acsomega.1c04961},
	author = {Kulkarni, Akshay S. and Ramesh, Remya and Walia, Safal and Sayyad, Shahebaz I. and Gathalkar, Ganesh B. and Balamkundu, Seetharamsing and Joshi, Manali and Sen, Avalokiteswar and Reddy, D. Srinivasa}
}
@article {48761,
	title = {Identification of new modulator of DNA repairing pathways based on natural product ({\textpm})-peharmaline A},
	journal = {Bioorganic \& Medicinal Chemistry},
	volume = {91},
	year = {2023},
	month = {AUG},
	pages = {117365},
	type = {Article},
	abstract = {<p>
	The complex heterogenic environment of tumour mass often leads to drug resistance and facilitate chemo insensitivity triggering more malignant phenotypes among cancer patients. Major DNA-damaging cancer drugs have been consistently proven unsuccessful in terms of elevating chemo-resistance. (\&amp; PLUSMN;)-peharmaline A, a hybrid natural product isolated from seeds of Peganum harmala L. possesses significant cytotoxic activities. Herein, we have described the design, and synthesis of a novel library of close and simplified analogues around the anticancer natural product (\&amp; PLUSMN;)-peharmaline A and investigated their cytotoxic activities, which led to the identification of three structurally simplified lead compounds exhibiting better potency than parent natural product. Among them, demethoxy analogue of peharmaline A was further investigated for its anticancer potential eliciting demethoxy analogue as potent DNA-damage inducing agent attenuating the expression of the proteins responsible for the DNA damage repair. Therefore, this demethoxy analogue warrants detailed investigations for the confirmations of the molecular mechanism-based studies responsible for its anticancer activity.</p>
},
	keywords = {DNA damage, EMT, Pictet, Spengler reaction, Structure-activity relationship, Total synthesis},
	issn = {0968-0896},
	doi = {10.1016/j.bmc.2023.117365},
	author = {Kulkarni, Akshay S. and Dash, Anshurekha and Shingare, Rahul D. and Chand, Jagdish and Manhas, Diksha and Singh, Aman and Nandi, Utpal and Goswami, Anindya and Reddy, D. Srinivasa}
}
@article {49913,
	title = {Interplay between genotoxic stress and STING activation in cellular senescence and inflammatory responses},
	journal = {International Immunopharmacology},
	volume = {164},
	year = {2025},
	month = {OCT},
	pages = {115371},
	type = {Article},
	abstract = {<p>
	STING pathway is activated by endogenous or exogenous DNA damage and is known to trigger cell-intrinsic innate immunity. In this study, we demonstrated that the Peharmaline analog NDS101781 is a potent genotoxic molecule to trigger cellular senescence via innate immune-responsive STING activation. We found NDS101781 consistently modulated the expression of DDR markers including gamma-H2AX, Rad51, PARP1, ATM and MRE11 in breast cancer cells with concomitant amplification in the hallmarks of senescence along with STING signaling mediators which is intricately involved in NDS101781-mediated senescence activation as evidenced by significant reduction in the senescent population in si-TMEM173-transfected cells. In vitro findings proclaimed that STING activation by NDS101781 is crucial for p21-mediated senescence augmentation, a process regulated by ATM and p53 via a pathway independent of cGAS. Although STING is activated by both canonical and non-canonical manner, our mechanistic findings indicated that ATM played a crucial role in early activation of NDS101781 driven STING signaling via p53 activation and stimulation of pTBK1, NF-kappa B, and p-IRF3, through a non-canonical cascade in cGAS-independent mechanism. The results also indicated that interference of canonical and non-canonical STING activation, responsible for NF-kappa B stimulation leading to IL-6 generation. Intriguingly, the inhibition of ATM diminished senescence hallmarks; however, suppression of ATM as well as p21 neutralization triggered apoptotic cascade and thus regulating the SASP factors. However, transient knockdown of p21 moderately instigated the apoptotic mediators underscoring that NDS101781 mediated senescence induction delayed programmed cell death under intact p21 conditions. Moreover, pharmacokinetics of NDS101781 confirmed its excellent half-life in a preclinical model and in vivo studies confirmed that NDS101781 significantly inhibited tumor growth in a syngeneic aggressive 4T1-p53 breast cancer model.</p>
},
	keywords = {ATM, IL-6, Peharmaline, Senescence, STING},
	issn = {1567-5769},
	doi = {10.1016/j.intimp.2025.115371},
	author = {Dash, Anshurekha and Kulkarni, Akshay S. and Irshad, Faisal and Masal, Dattatraya P. and Manhas, Diksha and Nandi, Utpal and Reddy, D. Srinivasa and Goswami, Anindya}
}
