@article {43217, title = {First synthesis of a noreremophilane isolated from the roots of ligularia przewalskii}, journal = {Tetrahedron Letters}, volume = {46}, year = {2005}, month = {AUG}, pages = {5211-5213}, abstract = {

The total synthesis of a natural product noreremophilane has been achieved in just three steps from readily available starting materials. A highly stereo- and regio-selective Diels-Alder reaction was the key step in Our synthesis. (c) 2005 Elsevier Ltd. All rights reserved.

}, doi = {10.1016/j.tetlet.2005.05.130}, author = {Reddy, D. Srinivasa and Palani, K. and Balasubrahmanyam, D. and Kamath, V. B. and Iqbal, Javed} } @article { ISI:000328864800072, title = {First total synthesis of hunanamycin A}, journal = {Organic Letters}, volume = {15}, number = {17}, year = {2013}, month = {SEP}, pages = {4556-4559}, publisher = {AMER CHEMICAL SOC}, address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA}, abstract = {

The first total synthesis of hunanamycin A, an antibiotic natural product with a pyrido[1,2,3-de]quinoxaline-2,3-dione core from a marine-derived Bacillus hunanensis, is disclosed. The present effort provides access to sufficient amounts of scarce hunanamycin A for further biological evaluation and confirmation of the assigned absolute configuration. In addition, four new analogues of the natural product are reported.

}, issn = {1523-7060}, doi = {10.1021/ol402110e}, author = {Shingare, Rahul D. and Velayudham, R. and Gawade, Jalindar R. and Reddy, D. Srinivasa} } @article { ISI:000350528300019, title = {First synthesis of nitrosporeusines, alkaloids with multiple biological activities}, journal = {Tetrahedron Letters}, volume = {56}, number = {10}, year = {2015}, month = {MAR}, pages = {1252-1254}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

Synthesis of nitrosporeusines A and B, thioester-bearing alkaloids from the Arctic Streptomyces nitrosporeus with exceptional biological activity is disclosed for the first time. In addition, we have prepared another biologically important natural product, maleimycin, in optically pure form using a gram-scale enzymatic resolution method. (C) 2015 Elsevier Ltd. All rights reserved.

}, keywords = {Enzymatic resolution, Influenza H1N1 virus, Maleimycin, Michael reaction, Nitrosporeusine}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2015.01.143}, author = {Philkhana, Satish Chandra and Jachak, Gorakhnath R. and Gunjal, Vidya B. and Dhage, Nagsen M. and Bansode, Ajay H. and Reddy, D. Srinivasa} } @article { ISI:000367701900032, title = {First total synthesis of gliomasolide C and formal total synthesis of sch-725674}, journal = {Journal of Organic Chemistry}, volume = {81}, number = {1}, year = {2016}, month = {JAN}, pages = {290-296}, publisher = {AMER CHEMICAL SOC}, address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA}, abstract = {

Syntheses of two 14-membered macrolides Sch-725674 and Gliomasolide C are described here. The first total synthesis of Gliomasolide C, the short synthesis of Sch-725674, and regios elective Wacker oxidation of internal olefin are the highlights of this disclosure. In addition, a key macrocyde with orthogonal functionalities was designed and synthesized on a gram scale for the generation of analogues.

}, issn = {0022-3263}, doi = {10.1021/acs.joc.5b02318}, author = {Seetharamsingh, B. and Khairnar, Pankaj V. and Reddy, D. Srinivasa} } @article {46649, title = {FeCl3-catalyzed oxidative decarboxylation of aryl/heteroaryl acetic acids: preparation of selected API impurities}, journal = {Organic \& Biomolecular Chemistry}, volume = {18}, year = {2020}, month = {NOV }, pages = {8459-8466}, type = {Article}, abstract = {

There is an ever-increasing demand for impurity compounds for use in impurity profiling as regulatory agencies seek information during registration. Herein, we report the FeCl3-catalyzed oxidative decarboxylation of aryl- and heteroaryl acetic acids to the corresponding carbonyl compounds. A variety of useful aldehydes and ketones were prepared in a simple one-pot transformation by employing an environmentally benign, low-cost, and readily available iron salt. The utility of this method has been demonstrated by preparing five valuable API impurities including a multi-gram-scale synthesis of ketorolac impurity B for the first time.

}, issn = {1477-0520}, doi = {10.1039/d0ob01790f}, author = {Gangadurai, Chinnakuzhanthai and Illa, Giri Teja and Reddy, D. Srinivasa} }